Reactome | Potassium Channels

Potassium Channels

Stable Identifier

R-HSA-1296071

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Potassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation of action potentials in cardiac muscle and help release of insulin form pancreatic beta cells.
Broadly K+ channels are classified into voltage gated K+ channels, Hyperpolarization activated cyclic nucleotide gated K+ channels (HCN), Tandem pore domain K+ channels, Ca2+ activated K+ channels and inwardly rectifying K+ channels.

Literature References

PubMed ID	Title	Journal	Year
20213494	HCN-related channelopathies Bottelli, G, DiFrancesco, D, Milanesi, R, Baruscotti, M, DiFrancesco, JC	Pflugers Arch	2010
1822292	New insights into the structure and function of potassium channels MacKinnon, R	Curr Opin Neurobiol	1991
19584315	Hyperpolarization-activated cation channels: from genes to function Biel, M, Wahl-Schott, C, Michalakis, S, Zong, X	Physiol Rev	2009
20086079	Inwardly rectifying potassium channels: their structure, function, and physiological roles Furutani, K, Findlay, I, Inanobe, A, Hibino, H, Murakami, S, Kurachi, Y	Physiol Rev	2010
20813163	Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes Foeger, NC, Nerbonne, JM, Norris, AJ	Neurosci Lett	2010
18446619	Surface expression and distribution of voltage-gated potassium channels in neurons (Review) Swanton, L, McKeown, L, Jones, OT, Robinson, P	Mol Membr Biol	2008
18413784	Potassium channels: newly found players in synaptic plasticity Hoffman, DA, Kim, J	Neuroscientist	2008