lpdC dimer reactivates dlaT

Stable Identifier
R-HSA-1222412
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).

Literature References
PubMed ID Title Journal Year
11799204 Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

Bryk, R, Lima, CD, Erdjument-Bromage, H, Tempst, P, Nathan, C

Science 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dihydrolipoyl dehydrogenase activity of lpdC dimer [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created