lpdC dimer reactivates dlaT

Stable Identifier
R-HSA-1222412
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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lpdC dimer reactivates dlaT
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Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).

Literature References
PubMed ID Title Journal Year
11799204 Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

Bryk, R, Lima, CD, Erdjument-Bromage, H, Tempst, P, Nathan, C

Science 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
dihydrolipoyl dehydrogenase activity of lpdC dimer [cytosol]
Physical Entity
lpdC dimer [cytosol]
Activity
dihydrolipoyl dehydrogenase activity (0004148)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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