LpdC dimer reactivates DlaT

Stable Identifier
R-HSA-1222412
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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LpdC dimer reactivates DlaT
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
Literature References
PubMed ID Title Journal Year
11799204 Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

Bryk, R, Lima, CD, Erdjument-Bromage, H, Tempst, P, Nathan, C

Science 2002
Participants
Input
Output
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as an event of
Catalyst Activity

dihydrolipoyl dehydrogenase (NADH) activity of LpdC dimer [cytosol]

Physical Entity
LpdC dimer [cytosol] (Mycobacterium tuberculosis)
Activity
dihydrolipoyl dehydrogenase (NADH) activity (GO:0004148)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Mondo
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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