Cell redox homeostasis

Stable Identifier
R-HSA-1222541
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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The most important response of Mtb to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006).

Literature References
PubMed ID Title Journal Year
21270886 The challenge of new drug discovery for tuberculosis

Koul, A, Arnoult, E, Lounis, N, Guillemont, J, Andries, K

Nature 2011
17012768 The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs

Jaeger, T, Flohé, L

Biofactors 2006
Participants
Participant Of
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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Reviewed
Created