phospho-PLA2 pathway

Stable Identifier
R-HSA-111995
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen, cytosol
ReviewStatus
5/5
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phospho-PLA2 pathway
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Phospholipase A2 (PLA2) enzymes hydrolyze arachidonic acid (AA) from the sn-2 position of phospholipids. AA is a precursor of eicosanoids, lipid mediators involved in inflammtory responses. PLA2 enzymes function as regulators of phospholipid acyl turnover, either as housekeepers for membrane repair or for the production of imflammatory lipid mediators. There are diverse forms of PLA2 enyzmes including secretory (sPLA2), calcium-independent and cytosolic (cPLA2). The cPLA2 form which mediates arachidonic acid release is annotated here.
Literature References
PubMed ID Title Journal Year
9201969 Properties and regulation of cytosolic phospholipase A2

Leslie, CC

J Biol Chem 1997
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Orthologous Events
phospho-PLA2 pathway (Bos taurus)
phospho-PLA2 pathway (Canis familiaris)
phospho-PLA2 pathway (Danio rerio)
phospho-PLA2 pathway (Gallus gallus)
phospho-PLA2 pathway (Mus musculus)
phospho-PLA2 pathway (Rattus norvegicus)
phospho-PLA2 pathway (Saccharomyces cerevisiae)
phospho-PLA2 pathway (Schizosaccharomyces pombe)
phospho-PLA2 pathway (Sus scrofa)
phospho-PLA2 pathway (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Schmidt, EE  (2004-03-31)
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