Phosphorylation of cPLA2 by ERK-2

Stable Identifier
R-HSA-111898
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Phosphorylation of cPLA2 by ERK-2
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ERK2 phosphorylates cPLA2, increasing enzymatic activity. The site of cPLA2 phosphorylation by ERK2 is Ser-505, the major site of cPLA2 phosphorylation observed in phorbol ester-treated cells.

Literature References
PubMed ID Title Journal Year
8381049 cPLA2 is phosphorylated and activated by MAP kinase

Davis, RJ, Knopf, JL, Seth, A, Wartmann, M, Lin, AY, Lin, LL

Cell 1993
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Output
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as an event of
Catalyst Activity

MAP kinase activity of p-T185,Y187-MAPK1 [cytosol]

Physical Entity
p-T185,Y187-MAPK1 [cytosol] (Homo sapiens)
Activity
MAP kinase activity (GO:0004707)
Orthologous Events
Phosphorylation of cPLA2 by ERK-2 (Bos taurus)
Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)
Phosphorylation of cPLA2 by ERK-2 (Danio rerio)
Phosphorylation of cPLA2 by ERK-2 (Dictyostelium discoideum)
Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)
Phosphorylation of cPLA2 by ERK-2 (Mus musculus)
Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)
Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)
Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)
Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)
Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Schmidt, EE  (2004-03-24)
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