Hydrolysis of phosphatidylcholine

Stable Identifier
R-HSA-111883
Type
Reaction
Species
Homo sapiens
Compartment
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Once bound to the membrane, cPLA2 hydrolyzes phosphatidylcholine to produce arachidonic acid (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes this reaction in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonic acid in some cell types or under some physiological conditions (Murakami et al. 2011). Here, the major role of PLA2G4A has been annotated.

Literature References
PubMed ID Title Journal Year
21746768 Secreted phospholipase A2 revisited

Taketomi, Y, Yamamoto, K, Sato, H, Murakami, M

J. Biochem. 2011
21247147 Functional characterization of mutations in inherited human cPLA? deficiency

Gelb, MH, Aloulou, A, Adler, D, Leslie, CC, Ghomashchi, F, Boutaud, O, Oates, JA, Reed, KA, Tucker, DE

Biochemistry 2011
Participants
Participates
Catalyst Activity

calcium-dependent phospholipase A2 activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]

Orthologous Events
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