Reactome | PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

Stable Identifier

R-HSA-111883

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol, endoplasmic reticulum lumen

Synonyms

1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H+

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        phospho-PLA2 pathway (Homo sapiens)
        
        PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Homo sapiens)

General

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Once associated with the endoplasmic reticulum membrane, PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine to produce arachidonate (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes it in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonate in some cell types or under some physiological conditions (Murakami et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21746768	Secreted phospholipase A2 revisited Taketomi, Y, Yamamoto, K, Sato, H, Murakami, M	J. Biochem.	2011
21247147	Functional characterization of mutations in inherited human cPLA? deficiency Gelb, MH, Aloulou, A, Adler, D, Leslie, CC, Ghomashchi, F, Boutaud, O, Oates, JA, Reed, KA, Tucker, DE	Biochemistry	2011