Reactome | Hydrolysis of phosphatidylcholine

Hydrolysis of phosphatidylcholine

Stable Identifier

R-HSA-111883

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol, endoplasmic reticulum lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        phospho-PLA2 pathway (Homo sapiens)
        
        Hydrolysis of phosphatidylcholine (Homo sapiens)

General

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Once bound to the membrane, cPLA2 hydrolyzes phosphatidylcholine to produce arachidonic acid (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes this reaction in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonic acid in some cell types or under some physiological conditions (Murakami et al. 2011). Here, the major role of PLA2G4A has been annotated.

Literature References

PubMed ID	Title	Journal	Year
21746768	Secreted phospholipase A2 revisited Taketomi, Y, Yamamoto, K, Sato, H, Murakami, M	J. Biochem.	2011
21247147	Functional characterization of mutations in inherited human cPLA? deficiency Gelb, MH, Aloulou, A, Adler, D, Leslie, CC, Ghomashchi, F, Boutaud, O, Oates, JA, Reed, KA, Tucker, DE	Biochemistry	2011