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CaMK IV-mediated phosphorylation of CREB
Stable Identifier
R-HSA-111932
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
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The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase kinase (CaMKK); and the CaM kinases CaMKI and CaMKIV, which are phosphorylated and activated by CaMKK. Members of this cascade respond to elevation of intracellular Ca2+ levels. CaMKK and CaMKIV localize both to the nucleus and to the cytoplasm, whereas CaMKI is only cytosolic. Nuclear CaMKIV regulates transcription through phosphorylation of several transcription factors, including CREB. In the cytoplasm, there is extensive cross-talk between CaMKK, CaMKIV and other signaling cascades, including those that involve the cAMP-dependent kinase (PKA), MAP kinases and protein kinase B (PKB/Akt).
Literature References
PubMed ID
Title
Journal
Year
10366852
The Ca-calmodulin-dependent protein kinase cascade
Soderling, TR
Trends Biochem Sci
1999
Participants
Events
CaMKII binds activated calmodulin
(Homo sapiens)
CaMKII autophosphorylates
(Homo sapiens)
CAMK4 binds KPNA2
(Homo sapiens)
CAMK4 enters the nucleus
(Homo sapiens)
Calmodulin-bound CaMKII-gamma enters the nucleus
(Homo sapiens)
Activated calmodulin dissociates from CaMKII-gamma
(Homo sapiens)
Calmodulin binds CAMK4
(Homo sapiens)
CaMKK binds activated calmodulin in the nucleus
(Homo sapiens)
CaMKK autophosphorylates in the nucleus
(Homo sapiens)
CaMKK phosphorylates CAMK4
(Homo sapiens)
CAMK4 autophosphorylates
(Homo sapiens)
CaMK4 phosphorylates CREB1
(Homo sapiens)
Dimerization of p-S133-CREB1
(Homo sapiens)
Participates
as an event of
Calmodulin induced events (Homo sapiens)
Orthologous Events
CaMK IV-mediated phosphorylation of CREB (Bos taurus)
CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
CaMK IV-mediated phosphorylation of CREB (Canis familiaris)
CaMK IV-mediated phosphorylation of CREB (Dictyostelium discoideum)
CaMK IV-mediated phosphorylation of CREB (Drosophila melanogaster)
CaMK IV-mediated phosphorylation of CREB (Gallus gallus)
CaMK IV-mediated phosphorylation of CREB (Mus musculus)
CaMK IV-mediated phosphorylation of CREB (Plasmodium falciparum)
CaMK IV-mediated phosphorylation of CREB (Rattus norvegicus)
CaMK IV-mediated phosphorylation of CREB (Schizosaccharomyces pombe)
CaMK IV-mediated phosphorylation of CREB (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000467
,
BIOMD0000000468
,
BIOMD0000000088
Authored
Jassal, B (2004-03-31)
Le Novere, N (2004-03-31)
Reviewed
Castagnoli, L (2008-11-06)
Created
Schmidt, EE (2004-03-25)
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