Reactome | CaMKII binds activated calmodulin

CaMKII binds activated calmodulin

Stable Identifier

R-HSA-442725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)

General

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CaMKII is fully activated upon binding to the complex of calcium and calmodulin (CALM1:4xCa2+), which forms upon influx of calcium ions through activated NMDA receptors. Autophosphorylation increases the affinity of CaMKII for the active calmodulin (CALM1:4xCa2+) (Meyer et al. 1992).

Participants

Input

Output

CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Participates

as an event of

Inferred From

CaMKII binds activated calmodulin (Rattus norvegicus)

Authored

Mahajan, SS (2009-10-29)

Reviewed

Tukey, D (2009-11-18)

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Mahajan, SS (2009-09-29)

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