Reactome | Calmodulin-bound CaMKII-gamma enters the nucleus

Calmodulin-bound CaMKII-gamma enters the nucleus

Stable Identifier

R-HSA-444792

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Synonyms

p-T287-CAMK2G:CALM1:4xCa2+ enters nucleus

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Calmodulin-bound CaMKII-gamma enters the nucleus

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Autophosphorylated, calmodulin-bound CaMKII-gamma (CAMK2G) translocates to the nucleus (Ma et al. 2014, Cohen et al. 2018). Translocation of CaMKII-gamma to the nucleus is positively regulated by activated CaMKII-beta through an unknown mechanism (Ma et al. 2014).

Participants

Input