Reactome | Calmodulin-bound CaMKII-gamma enters the nucleus

Calmodulin-bound CaMKII-gamma enters the nucleus

Stable Identifier

R-HSA-444792

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Synonyms

p-T287-CAMK2G:CALM1:4xCa2+ enters nucleus

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)

General

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Calmodulin-bound CaMKII-gamma enters the nucleus

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Autophosphorylated, calmodulin-bound CaMKII-gamma (CAMK2G) translocates to the nucleus (Ma et al. 2014, Cohen et al. 2018). Translocation of CaMKII-gamma to the nucleus is positively regulated by activated CaMKII-beta through an unknown mechanism (Ma et al. 2014).

Participants

Input

p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Output

p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Participates

as an event of

This event is regulated

Positively by

Regulator

p-T287-CAMK2B dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Inferred From

CaM-bound CaMKII-gamma enters the nucleus (Rattus norvegicus)

Authored

Mahajan, SS (2009-10-29)

Reviewed

Tukey, D (2009-11-17)

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Mahajan, SS (2009-10-26)

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