Reactome | MCFD2 [ER to Golgi transport vesicle membrane]

MCFD2 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-1017216

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

Multiple coagulation factor deficiency protein 2, MCFD2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)
        
        LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NI22 MCFD2

Gene Names

MCFD2, SDNSF

Chain

signal peptide:1-26, chain:27-146

Reference Genes

BioGPS Gene:90411 MCFD2

COSMIC (genes):MCFD2 MCFD2

CTD Gene:90411 MCFD2

dbSNP Gene:90411 MCFD2

ENSEMBL:ENSG00000180398 MCFD2

ENSEMBL:ENSG00000180398.13 MCFD2

HGNC:18451 MCFD2

KEGG Gene (Homo sapiens):90411 MCFD2

Monarch:90411 MCFD2

NCBI Gene:90411 MCFD2

OMIM:607788 MCFD2

UCSC:Q8NI22 MCFD2

Reference Transcript

Other Identifiers

11717009_s_at

11717010_a_at

11745178_a_at

11748317_s_at

212245_PM_at

212245_at

212246_PM_at

212246_at

2551787

2551788

2551789

2551790

2551791

2551794

2551797

2551798

2551799

2551804

2551805

2551809

38727_at

8051998

90411

A_23_P120270

A_24_P103060

GE57876

GO:0005509

GO:0005515

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0012507

GO:0015031

GO:0016192

GO:0031410

GO:0033116

GO:0043226

GO:0046872

HMNXSV003030684

Hs.84775.0.S1_3p_at

Hs.84775.0.S1_3p_x_at

Hs.84775.0.S2_3p_at

ILMN_1761808

ILMN_2202790

M23161_at

PH_hs_0023555

Participates

as a component of

Other forms of this molecule

MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

MCFD2 [endoplasmic reticulum membrane]

Inferred To

hm:zeh1186 [ER to Golgi transport vesicle membrane] (Danio rerio)

MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)

MCFD2 [ER to Golgi transport vesicle membrane] (Canis familiaris)

MCFD2 [ER to Golgi transport vesicle membrane] (Gallus gallus)

MCFD2 [ER to Golgi transport vesicle membrane] (Mus musculus)

MCFD2 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

MCFD2 [ER to Golgi transport vesicle membrane] (Sus scrofa)

Cross References

RefSeq

NP_001164982.1, NP_001164979.1, NP_001164980.1, NP_001164981.1, NP_644808.1, NP_001164978.1, NP_001164977.1

OpenTargets

ENSG00000180398

GeneCards

Q8NI22

HPA

ENSG00000180398-MCFD2

Ensembl

ENSP00000317271, ENSP00000387202, ENSP00000386941, ENSP00000386279, ENSP00000386261, ENSP00000394647, ENST00000409218, ENST00000409800, ENST00000409913, ENST00000409207, ENST00000412438, ENST00000409105, ENSP00000402717, ENST00000444761, ENSP00000387082, ENSP00000386386, ENST00000409147, ENST00000319466, ENSG00000180398, ENST00000409973, ENSP00000386651

PRO

Q8NI22

Pharos - Targets

Q8NI22

Orphanet

16385

HMDB Protein

HMDBP07789

PDB

3WHT, 3LCP, 4YGC, 4YGB, 4YGD, 3A4U, 2VRG, 3WHU, 4YGE, 3WNX

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3

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