Reactome | MCFD2 [ER to Golgi transport vesicle membrane]

MCFD2 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-BTA-1017216

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

MCFD2, A0A3Q1MFL2

Locations in the PathwayBrowser

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Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Asparagine N-linked glycosylation (Bos taurus)
    - Transport to the Golgi and subsequent modification (Bos taurus)
      - ER to Golgi Anterograde Transport (Bos taurus)
        
        COPII-mediated vesicle transport (Bos taurus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        CSNK1D phosphorylates SEC23 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        Nucleotide exchange on RAB1 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        Vesicle budding (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - ER to Golgi Anterograde Transport (Bos taurus)
    - COPII-mediated vesicle transport (Bos taurus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
      - CSNK1D phosphorylates SEC23 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
      - Nucleotide exchange on RAB1 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
      - Vesicle budding (Bos taurus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)
        
        MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MFL2

Gene Names

MCFD2

Reference Genes

ENSEMBL:ENSBTAG00000003358.6

UCSC:A0A3Q1MFL2 MCFD2

Other Identifiers

616647

Bt.5173.1.A1_at

GO:0005509

Participates

as a component of

hexameric LMAN1:MCFD2 [ER to Golgi transport vesicle membrane] (Bos taurus)

Other forms of this molecule

MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

MCFD2 [endoplasmic reticulum membrane]

Inferred From

MCFD2 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAP00000067747, ENSBTAT00000077670, ENSBTAG00000003358

VGNC

31304

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