phosphorylation of IRAK2 by activated IRAK4

Stable Identifier
R-GGA-434047
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created