phosphorylation of IRAK2 by activated IRAK4

Stable Identifier
R-GGA-434047
Type
Reaction [transition]
Species
Gallus gallus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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phosphorylation of IRAK2 by activated IRAK4
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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T

Nat Immunol 2008
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Output
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Catalyst Activity

protein serine/threonine kinase activity of IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane]

Physical Entity
IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2009-08-27)
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