Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88

Stable Identifier
R-GGA-433961
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88
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Cloning and analysis of full length chicken MyD88 revealed an open reading frame which encodes a predicted protein sequence of 368 amino acids (aa). Two more chicken MyD88 isoforms with 299 and 376 residues are described in the literature [Qiu Y et al 2008, Lynn et al 2003]. The amino acid sequences of the chMyD88 368 and 376 residue isoforms are 99% identical, 97% identical to the 299 aa chMyD88 predicted peptide and 68% identical to human MyD88 (296 aa).

Chicken MyD88 is recruited to the activated hetero or homodimer of chTLR that is located either on plasma membrane (TLR4, TLR2/1, TLR5 and TLR15) or endosome membrane (TLR7 and TLR21).

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Yamamoto, M, Sato, S, Hemmi, H, Hoshino, K, Kaisho, T, Sanjo, H, Takeuchi, O, Sugiyama, M, Okabe, M, Takeda, K

Science 2003
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T, Barton, GM, Flavell, RA, Medzhitov, R

Nature 2002
19679662 Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases

Loiarro, M, Gallo, G, Fantò, N, De Santis, R, Carminati, P, Ruggiero, V, Sette, C

J Biol Chem 2009
18582498 Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88)

Qiu, Y, Shen, Y, Li, X, Ding, C, Ma, Z

Dev Comp Immunol 2008
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Output
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as an event of
Inferred From
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2009-08-27)
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