Reactome | Autophosphorylation of chicken IRAK4

Autophosphorylation of chicken IRAK4

Stable Identifier

R-GGA-434018

Type

Reaction [transition]

Species

Gallus gallus

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - Autophosphorylation of chicken IRAK4 (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - Autophosphorylation of chicken IRAK4 (Gallus gallus)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chicken IRAK4 shows 66% amino acid identity to human IRAK4. It is assumed here that chicken IRAK4 is activated by autophosphorylation like its human homologue.

Literature References

PubMed ID	Title	Journal	Year
18438411	Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T	Nat Immunol	2008
14625308	Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C	J Biol Chem	2004