Autophosphorylation of chicken IRAK4

Stable Identifier
R-GGA-434018
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
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Chicken IRAK4 shows 66% amino acid identity to human IRAK4. It is assumed here that chicken IRAK4 is activated by autophosphorylation like its human homologue.

Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU

J Biol Chem 2004
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of activated TLR homo- or heterodimer : TIRAP :MyD88 :IRAK4 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created