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SkpA [cytosol]
Stable Identifier
R-DME-174150
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
SKP1, O77430
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Drosophila melanogaster)
Formation of the SCF-FBXL7 complex (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)
SCF-FBXL7:AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF:FBXL7 binds AURKA (Drosophila melanogaster)
SCF-FBXL7:AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
SCF-beta-TrCP mediated degradation of Emi1 (Drosophila melanogaster)
Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Drosophila melanogaster)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
Iron uptake and transport (Drosophila melanogaster)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:FBXL5 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O77430 skpA
Gene Names
skpA, Dredd, EG:115C2.4, CG16983, Dmel_CG16983
Reference Genes
BioGPS Gene:31016 skpA
KEGG Gene (Drosophila melanogaster):Dmel_CG16983 skpA
Monarch:31016 skpA
NCBI Gene:31016 skpA
UCSC:O77430 skpA
Reference Transcript
RefSeq:NM_166856.3 skpA
RefSeq:NM_166857.3 skpA
RefSeq:NM_166858.3 skpA
RefSeq:NM_166859.3 skpA
RefSeq:NM_001297826.1 skpA
RefSeq:NM_001038729.3 skpA
RefSeq:NM_166860.3 skpA
RefSeq:NM_058042.5 skpA
RefSeq:NM_166861.3 skpA
Other Identifiers
153376_at
1625801_s_at
31016
GO:0000278
GO:0002376
GO:0002785
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006260
GO:0006511
GO:0007010
GO:0007059
GO:0012501
GO:0016322
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030261
GO:0031146
GO:0031647
GO:0032436
GO:0034330
GO:0035331
GO:0036211
GO:0042023
GO:0043066
GO:0043226
GO:0045886
GO:0045931
GO:0046329
GO:0046627
GO:0048856
GO:0051298
GO:0060090
GO:0061060
GO:0090090
GO:0097602
GO:0098542
GO:0140013
GO:1905088
Participates
as a component of
NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
SKP1:CUL1:FBXL5 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
as an input of
Formation of the SCF-FBXL7 complex (Drosophila melanogaster)
Other forms of this molecule
SKPA [cytosol]
SkpA [nucleoplasm]
Inferred From
SKP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_726695.1
,
NP_726693.1
,
NP_477390.1
,
NP_001033818.1
,
NP_726694.1
,
NP_726691.1
,
NP_726690.1
,
NP_726692.1
,
NP_001284755.1
Flybase
FBgn0025637
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VDE3 Q9VDE3
0.83
7
UniProt:Q9V6L9 FBSP1
0.667
3
UniProt:Q9VIW8 Q9VIW8
0.667
4
UniProt:Q9VZF4 FBXW7
0.667
3
UniProt:Q9VNX7
1
FBXL12 [cytosol]
(R-DME-8850912)
0.667
3
UniProt:Q9Y165 Q9Y165
0.641
3
UniProt:Q8SX86 NUTC
0.621
3
UniProt:Q8IGU5 Q8IGU5
0.553
2
UniProt:Q9VED4 Q9VED4
0.553
2
UniProt:Q9W214 Q9W214
0.553
2
UniProt:Q9VKF2 Q9VKF2
0.553
2
UniProt:Q7YZ95
5
Skp2 [nucleoplasm]
(R-DME-9708570)
Skp2 [cytosol]
(R-DME-8854063)
Skp2 [cytosol]
(R-DME-975495)
Skp2 [nucleoplasm]
(R-DME-9687073)
Skp2 [nucleoplasm]
(R-DME-975554)
0.553
2
UniProt:Q961T2 Q961T2
0.547
2
UniProt:Q9VM76
6
phospho-Rca1 [nucleoplasm]
(R-DME-163049)
phospho-Rca1 [nucleoplasm]
(R-DME-174220)
phospho-Rca1 [nucleoplasm]
(R-DME-176447)
Rca1 [nucleoplasm]
(R-DME-174060)
phospho-Rca1 [cytosol]
(R-DME-174207)
phospho-Rca1 [cytosol]
(R-DME-177324)
0.547
3
UniProt:Q24311 Cul1
4
LIN19 [cytosol]
(R-DME-206151)
Cul1 [cytosol]
(R-DME-8952519)
Cul1 [nucleoplasm]
(R-DME-187551)
Cul1 [cytosol]
(R-DME-174230)
0.534
3
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