Reactome | Skp2 [cytosol]

Skp2 [cytosol]

Stable Identifier

R-DME-975495

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

SKP2, Q7YZ95

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
    - Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
      - Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - Polyubiquitination of substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Neddylation (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
        
        CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Skp2 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7YZ95

Gene Names

Skp2

Reference Genes

BioGPS Gene:40548 Skp2

ENSEMBL:FBgn0037236

FlyBase:FBgn0037236

KEGG Gene (Drosophila melanogaster):Dmel_CG9772 Skp2

Monarch:40548 Skp2

NCBI Gene:40548 Skp2

UCSC:Q7YZ95 Skp2

Reference Transcript

Other Identifiers

153298_at

1637091_a_at

40548

GO:0000278

GO:0003824

GO:0005515

GO:0007113

GO:0016301

GO:0016310

GO:0016740

GO:0019005

GO:0030163

GO:0031146

GO:0031647

GO:0035220

GO:0045787

GO:0048749

GO:0048856

Participates

as a member of

F-box protein [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Skp2 [nucleoplasm]

Skp2 [cytosol]

Skp2 [nucleoplasm]

Inferred From

SKP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_730815.2, NP_730816.3

Flybase

FBgn0037236

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O77430 skpA	3	SKPA [cytosol] (R-DME-205785) SkpA [nucleoplasm] (R-DME-187538) SkpA [cytosol] (R-DME-174150)	0.553	2
UniProt:Q9VHN1 Q9VHN1			0.553	3

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