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SKPA [cytosol]
Stable Identifier
R-DME-205785
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
SKPA [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O77430 skpA
Gene Names
skpA, Dredd, EG:115C2.4, CG16983, Dmel_CG16983
Reference Genes
BioGPS Gene:31016 skpA
KEGG Gene (Drosophila melanogaster):Dmel_CG16983 skpA
Monarch:31016 skpA
NCBI Gene:31016 skpA
UCSC:O77430 skpA
Reference Transcript
RefSeq:NM_166856.3 skpA
RefSeq:NM_166857.3 skpA
RefSeq:NM_166858.3 skpA
RefSeq:NM_166859.3 skpA
RefSeq:NM_001297826.1 skpA
RefSeq:NM_001038729.3 skpA
RefSeq:NM_166860.3 skpA
RefSeq:NM_058042.5 skpA
RefSeq:NM_166861.3 skpA
Other Identifiers
153376_at
1625801_s_at
31016
GO:0000278
GO:0002376
GO:0002785
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006260
GO:0006511
GO:0007010
GO:0007059
GO:0012501
GO:0016322
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030261
GO:0031146
GO:0031647
GO:0032436
GO:0034330
GO:0035331
GO:0036211
GO:0042023
GO:0043066
GO:0043226
GO:0045886
GO:0045931
GO:0046329
GO:0046627
GO:0048856
GO:0051298
GO:0060090
GO:0061060
GO:0090090
GO:0097602
GO:0098542
GO:0140013
GO:1905088
Participates
as a component of
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] (Drosophila melanogaster)
Other forms of this molecule
SkpA [nucleoplasm]
SkpA [cytosol]
Cross References
RefSeq
NP_726695.1
,
NP_726693.1
,
NP_477390.1
,
NP_001033818.1
,
NP_726694.1
,
NP_726691.1
,
NP_726690.1
,
NP_726692.1
,
NP_001284755.1
Flybase
FBgn0025637
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VDE3 Q9VDE3
0.83
7
UniProt:Q9V6L9 FBSP1
0.667
3
UniProt:Q9VIW8 Q9VIW8
0.667
4
UniProt:Q9VZF4 FBXW7
0.667
3
UniProt:Q9VNX7
1
FBXL12 [cytosol]
(R-DME-8850912)
0.667
3
UniProt:Q9Y165 Q9Y165
0.641
3
UniProt:Q8SX86 NUTC
0.621
3
UniProt:Q8IGU5 Q8IGU5
0.553
2
UniProt:Q9VED4 Q9VED4
0.553
2
UniProt:Q9W214 Q9W214
0.553
2
UniProt:Q9VKF2 Q9VKF2
0.553
2
UniProt:Q7YZ95
5
Skp2 [nucleoplasm]
(R-DME-9708570)
Skp2 [cytosol]
(R-DME-8854063)
Skp2 [cytosol]
(R-DME-975495)
Skp2 [nucleoplasm]
(R-DME-9687073)
Skp2 [nucleoplasm]
(R-DME-975554)
0.553
2
UniProt:Q961T2 Q961T2
0.547
2
UniProt:Q9VM76
6
phospho-Rca1 [nucleoplasm]
(R-DME-163049)
phospho-Rca1 [nucleoplasm]
(R-DME-174220)
phospho-Rca1 [nucleoplasm]
(R-DME-176447)
Rca1 [nucleoplasm]
(R-DME-174060)
phospho-Rca1 [cytosol]
(R-DME-174207)
phospho-Rca1 [cytosol]
(R-DME-177324)
0.547
3
UniProt:Q24311 Cul1
4
LIN19 [cytosol]
(R-DME-206151)
Cul1 [cytosol]
(R-DME-8952519)
Cul1 [nucleoplasm]
(R-DME-187551)
Cul1 [cytosol]
(R-DME-174230)
0.534
3
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