Reactome | CUL1:FBXW11:SKP1 [cytosol]

CUL1:FBXW11:SKP1 [cytosol]

Stable Identifier

R-DME-1168592

Type

Complex

Species

Drosophila melanogaster

Compartment

cytosol

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Cul1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
SkpA [cytosol] (Drosophila melanogaster)

Participates

as an input of

SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)

as an output of

SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)
SCF-beta-TrCP ubiquitinylates IkB (Drosophila melanogaster)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)

as a component of

p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Drosophila melanogaster)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Drosophila melanogaster)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Drosophila melanogaster)

Inferred From

SCF-beta-TRCP [cytosol] (Homo sapiens)

(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)

CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)

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