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Cul1 [nucleoplasm]
Stable Identifier
R-DME-187551
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
CUL1, Q24311
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
BTRC binds p-S344, 347 NFE2L2 (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Regulation of BACH1 activity (Drosophila melanogaster)
BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
Regulation of RUNX2 expression and activity (Drosophila melanogaster)
SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Cul1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24311 Cul1
Gene Names
Cul1, cul-1, lin19, CG1877
Chain
chain:1-774
Reference Genes
BioGPS Gene:35742 Cul1
KEGG Gene (Drosophila melanogaster):Dmel_CG1877 Cul1
Monarch:35742 Cul1
NCBI Gene:35742 Cul1
UCSC:Q24311 Cul1
Reference Transcript
RefSeq:NM_165571.2 Cul1
RefSeq:NM_165570.3 Cul1
RefSeq:NM_078931.4 Cul1
RefSeq:NM_165569.2 Cul1
Other Identifiers
153960_at
1624407_s_at
35742
GO:0002376
GO:0002785
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006511
GO:0007059
GO:0012501
GO:0014067
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030674
GO:0031146
GO:0031398
GO:0031461
GO:0031625
GO:0032436
GO:0035331
GO:0036211
GO:0043066
GO:0043226
GO:0045879
GO:0046627
GO:0048856
GO:0051898
GO:0060090
GO:0061060
GO:0070979
GO:0090090
GO:0098542
GO:0140013
GO:1904801
GO:1905088
Participates
as a component of
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
LIN19 [cytosol]
Cul1 [cytosol]
Cul1 [cytosol]
Inferred From
CUL1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_724621.1
,
NP_724623.1
,
NP_724622.1
,
NP_523655.1
Flybase
FBgn0015509
PRO
Q24311
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O77430 skpA
3
SKPA [cytosol]
(R-DME-205785)
SkpA [nucleoplasm]
(R-DME-187538)
SkpA [cytosol]
(R-DME-174150)
0.534
3
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