Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pp1a-nsp6-11 [cytosol]
Stable Identifier
R-COV-9694668
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
Synonyms
P0DTC1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
pp1a-nsp6-11 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Maturation of replicase proteins (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
pp1a-nsp6-11 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
3CLp cleaves pp1a (Homo sapiens)
pp1a-nsp6-11 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
pp1a cleaves itself (Homo sapiens)
pp1a-nsp6-11 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
General
SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).
External Reference Information
External Reference
UniProt:P0DTC1 pp1a
Gene Names
pp1a
Chain
chain:1-4405, chain:1-180, chain:181-818, chain:819-2763, chain:2764-3263, chain:3264-3569, chain:3570-3859, chain:3860-3942, chain:3943-4140, chain:4141-4253, chain:4254-4392, chain:4393-4405
Participates
as an input of
3CLp cleaves nsp6-11 (Homo sapiens)
as an output of
pp1a cleaves itself (Homo sapiens)
3CLp cleaves pp1a (Homo sapiens)
This entity regulates
Positively
Enhanced autophagosome formation
(Homo sapiens)
Other forms of this molecule
pp1a-nsp6 [nuclear envelope]
pp1a-nsp7 [cytosol]
pp1a-nsp11 [cytosol]
pp1a-nsp9 [cytosol]
N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
pp1a-nsp3-4 [cytosol]
pp1a-nsp3 [cytosol]
pp1a-nsp2 [cytosol]
pp1a-nsp1 [cytosol]
pp1a-nsp4 [cytosol]
N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
pp1a-nsp6 [endoplasmic reticulum membrane]
N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
pp1a-nsp4 [double membrane vesicle viral factory outer membrane]
pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
N6GMPLys-pp1a-nsp7 [cytosol]
pp1a-nsp10 [cytosol]
pp1a-nsp1-4 [cytosol]
pp1a [cytosol]
pp1a-3CL [cytosol]
pp1a-nsp8 [cytosol]
Inferred From
pp1a-nsp6-11 [cytosol]
(Human SARS coronavirus)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text