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pp1a-nsp6 [endoplasmic reticulum membrane]
Stable Identifier
R-COV-9694256
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane
Synonyms
P0DTC1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
pp1a-nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp6 localizes to the nuclear envelope (Homo sapiens)
nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
pp1a-nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)
nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
pp1a-nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
General
SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).
External Reference Information
External Reference
UniProt:P0DTC1 pp1a
Gene Names
pp1a
Chain
chain:1-4405, chain:1-180, chain:181-818, chain:819-2763, chain:2764-3263, chain:3264-3569, chain:3570-3859, chain:3860-3942, chain:3943-4140, chain:4141-4253, chain:4254-4392, chain:4393-4405
Reference Genes
BioGPS Gene:43740578
Monarch:43740578
NCBI Gene:43740578
UCSC:P0DTC1
Reference Transcript
RefSeq:NC_045512.2 E
Participates
as an output of
3CLp cleaves nsp6-11 (Homo sapiens)
as a member of
nsp6 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Other forms of this molecule
pp1a-nsp8 [cytosol]
pp1a-3CL [cytosol]
pp1a [cytosol]
pp1a-nsp1-4 [cytosol]
pp1a-nsp6-11 [cytosol]
pp1a-nsp10 [cytosol]
N6GMPLys-pp1a-nsp7 [cytosol]
pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
pp1a-nsp4 [double membrane vesicle viral factory outer membrane]
pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
pp1a-nsp4 [cytosol]
pp1a-nsp1 [cytosol]
pp1a-nsp2 [cytosol]
pp1a-nsp3 [cytosol]
pp1a-nsp3-4 [cytosol]
N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
pp1a-nsp9 [cytosol]
pp1a-nsp11 [cytosol]
pp1a-nsp7 [cytosol]
pp1a-nsp6 [nuclear envelope]
Inferred From
pp1a-nsp6 [endoplasmic reticulum membrane]
(Human SARS coronavirus)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009725295.1
Mondo
0100096
IntEnz
2.7.7.50
PDB
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