pp1a cleaves itself

Stable Identifier
R-HSA-9694377
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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pp1a cleaves itself
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The crucial step of autocleavage of pp1a involves the formation of an "intermediate" pp1a dimer which has weak protease activity. This "embedded" 3CLp liberates itself by cleaving the ends off its monomer in trans. Only after that occurs does the cleaved 3CLp form a dimer, the most efficient form of the enzyme (Noske et al, 2021).
Literature References
PubMed ID Title Journal Year
34174328 A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process

Noske, GD, Nakamura, AM, Gawriljuk, VO, Fernandes, RS, Lima, GMA, Rosa, HVD, Pereira, HD, Zeri, ACM, Nascimento, AFZ, Freire, MCLC, Fearon, D, Douangamath, A, von Delft, F, Oliva, G, Godoy, AS

J Mol Biol 2021
Participants
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Output
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Catalyst Activity

cysteine-type endopeptidase activity of pp1a dimer [cytosol]

Physical Entity
pp1a dimer [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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