pp1a-nsp4 [double membrane vesicle viral factory outer membrane]

Stable Identifier
R-COV-9694767
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
double membrane vesicle viral factory outer membrane
Synonyms
pp1a-ns4, Non-strucutral protein 4
Locations in the PathwayBrowser
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General
SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).
Literature References
PubMed ID Title Journal Year
17855519 Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication

Oostra, M, te Lintelo, EG, Deijs, M, Verheije, MH, Rottier, PJ, de Haan, CA

J. Virol. 2007
External Reference Information
External Reference
UniProt:P0DTC1 pp1a
Gene Names
pp1a
Chain
chain:1-4405, chain:1-180, chain:181-818, chain:819-2763, chain:2764-3263, chain:3264-3569, chain:3570-3859, chain:3860-3942, chain:3943-4140, chain:4141-4253, chain:4254-4392, chain:4393-4405
Reference Genes
BioGPS Gene:43740578
Monarch:43740578
NCBI Gene:43740578
UCSC:P0DTC1
Reference Transcript
Participates
as a member of
Other forms of this molecule
pp1a-nsp8 [cytosol]
pp1a-3CL [cytosol]
pp1a [cytosol]
pp1a-nsp1-4 [cytosol]
pp1a-nsp6-11 [cytosol]
pp1a-nsp10 [cytosol]
N6GMPLys-pp1a-nsp7 [cytosol]
pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
pp1a-nsp6 [endoplasmic reticulum membrane]
N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
pp1a-nsp4 [cytosol]
pp1a-nsp1 [cytosol]
pp1a-nsp2 [cytosol]
pp1a-nsp3 [cytosol]
pp1a-nsp3-4 [cytosol]
N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
pp1a-nsp9 [cytosol]
pp1a-nsp11 [cytosol]
pp1a-nsp7 [cytosol]
pp1a-nsp6 [nuclear envelope]
Inferred From
pp1a-nsp4 [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
Modified Residues
Name
N-glycosylated residue at 2871
Coordinate
2871
PsiMod Name
N-glycosylated residue
PsiMod Definition
A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
Mondo
IntEnz
PDB
7TIW, 7EN9, 8HI9, 7UJU, 8CX9, 8J37, 8UUU, 8WS3, 7QCG, 8HOL, 7D47, 9GF7, 7XQ7, 7DPU, 6YHU, 7VK8, 7WYM, 7VU6, 8HVN, 8HVV, 8IHO, 8GWG, 7DHJ, 7UJG, 8SXO, 7VK5, 7NT1, 8GXI, 9EWM, 7U29, 8GQC, 8WUR, 8IGA, 7EIZ, 8CA6, 8AJ1, 9BRX, 8IG7, 8HUV, 8C9O, 7QL8, 7D64, 8J35, 8U25, 7QCK, 7TIU, 7XC4, 8YKP, 7X6J, 7FAY, 8R26, 7TUU, 8Z4W, 8C9L, 7YBG, 9GIJ, 7V7M, 8HVO, 8H5F, 7KOL, 8H57, 7DGH, 7VFA, 8HQG, 8RV6, 8R12, 8HHT, 7RBR, 8H82, 7EIN, 9BNT, 8YKJ, 7NT2, 8HVK, 9FQ9, 8C9U, 7NTT, 9EWN, 8Y44, 7VVT, 8YLS, 8H51, 8RV5, 7DGG, 9LVT, 8Y7T, 8CRM, 8R0V, 7VIC, 7D3I, 9L09, 7TVX, 7DK1, 7TIV, 7TIA, 8GXG, 8UFM, 7TIY, 7QCM, 8R1Q, 8GWM, 8IGY, 8Y42, 7E35, 7DAT, 7RBS, 7VK0, 8B0T, 7DGB, 8H7W, 7NWX, 8WSI, 7TLL, 8IFS, 7NT3, 8AZP, 8RV8, 8CAJ, 7D6H, 8WTI, 7U28, 7EXM, 8AZC, 7JIV, 7M1Y, 8C9P, 9CYB, 8W1T, 8TYK, 7WZO, 8GWK, 7SGV, 7XB4, 9IZB, 9FX6, 8UUW, 8IFT, 7EN8, 8GXH, 7TZJ, 7XQ6, 6Y2G, 8UHO, 7BV2, 8Z1H, 8H5P, 7DAU, 8YWY, 8RZC, 7VJW, 8GWF, 7VK1, 8CRF, 7KOK, 7JIR, 8RV4, 7WYP, 7VK4, 9BO4, 9GMQ, 8R11, 8YKM, 8IG4, 7X6K, 9CYD, 7JIW, 8WZ0, 8AZD, 9BRW, 9CYK, 8IG9, 8RZE, 7OFS, 8AZM, 8UOB, 7XRS, 9LVV, 7Z0P, 8C9Q, 7QCI, 8YA5, 9FZK, 7SGW, 7VLP, 7XC3, 7XAR, 7UV5, 9BLF, 9GIL, 7W9G, 7NXH, 8HQJ, 7NTV, 7DCD, 8HVX, 7VJZ, 8AYS, 7VK2, 8HBK, 9BO8, 7VK6, 7UJ9, 8GVY, 8CAC, 7TVS, 9FQA, 8DKJ, 9FW2, 8HUR, 9CYC, 8HZR, 9IK2, 9HAJ, 7NUK, 8H3L, 7JN2, 7OFU, 8RZD, 8HTV, 8AZI, 7VTH, 9FZ4, 8EIR, 7TIX, 8DI3, 7WO2, 7QCJ, 7C33, 8RVB, 7SGU, 7XB3, 9BO0, 7KRX, 7WOF, 6Y2E, 7VH8, 8GWO, 8H6I, 7VK3, 8HVY, 7DGF, 8IGX, 7JIT, 8H7K, 7VK7, 7SQE, 8B0S, 8GWB, 7FAZ, 8H4Y, 9EWO, 8GZB, 8ILC, 8UUV, 9GLV, 8HVZ, 8HVM, 8AZO, 7TOB, 9HAK, 8CA8, 8IG8, 7V1T, 8IGO, 7NW2, 8I30, 8HUX, 7Z4S, 9EPL, 7WO1, 8SPJ, 7TIZ, 7DJR, 8GWI, 8GQT, 8RV9, 8YKQ, 8IFR, 9CSY, 7QCH, 7VLQ, 6Y2F, 8H6N, 8WZP, 7VJY, 7NTW, 8GTV, 8HUW, 6YYT, 8GY6, 8R16, 8GWE, 8RV7, 8FIG, 8G62, 8UUF, 8IFQ, 9BBP, 8J3A, 8AZN, 8IGB, 8WSK, 7VJX, 8Y7U, 7KOJ, 8H3G, 7VFB, 8HQH, 8JOP, 7OFT, 8RVA, 8R19, 8HOM, 8UIA, 7TJ0, 8HOZ, 9EPM, 7WQB, 7CZ4, 8YKN, 8R24, 8GWN, 7WO3, 8IGN, 8HVW, 8Z46, 7DAV, 8GTW, 8HQI, 8R14, 7DGI, 8HBL, 7SDR, 8UUY, 8GW1, 9HJH, 8GVD, 7RZC, 7NTQ, 7DPP, 8J3B, 7JRN, 8HVU, 8H3K, 8HVL, 8HHU, 8IFP, 7DPV, 8AZL, 8UUH
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