Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Mn2+ [extracellular region]
Stable Identifier
R-ALL-266099
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Manganese, manganese(2+), Mn(II)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Fibronectin matrix formation (Bos taurus)
FN1 aggregation (Bos taurus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Metal sequestration by antimicrobial proteins (Bos taurus)
S100A8:S100A9 binds Mn2+ (Bos taurus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
Metabolism (Bos taurus)
Metabolism of carbohydrates (Bos taurus)
Blood group systems biosynthesis (Bos taurus)
ABO blood group biosynthesis (Bos taurus)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)
sABO-A:Mn2+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)
sABO-B:Mn2+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)
Mn2+ [extracellular region]
Extracellular matrix organization (Caenorhabditis elegans)
Fibronectin matrix formation (Caenorhabditis elegans)
FN1 aggregation (Caenorhabditis elegans)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Cell surface interactions at the vascular wall (Caenorhabditis elegans)
Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)
Mn2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Fibronectin matrix formation (Canis familiaris)
FN1 aggregation (Canis familiaris)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Metal sequestration by antimicrobial proteins (Canis familiaris)
S100A8:S100A9 binds Mn2+ (Canis familiaris)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
Metabolism (Canis familiaris)
Metabolism of carbohydrates (Canis familiaris)
Blood group systems biosynthesis (Canis familiaris)
ABO blood group biosynthesis (Canis familiaris)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)
sABO-A:Mn2+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)
sABO-B:Mn2+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)
Mn2+ [extracellular region]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Metal sequestration by antimicrobial proteins (Danio rerio)
S100A8:S100A9 binds Mn2+ (Danio rerio)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
Metabolism (Danio rerio)
Metabolism of carbohydrates (Danio rerio)
Blood group systems biosynthesis (Danio rerio)
ABO blood group biosynthesis (Danio rerio)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)
sABO-A:Mn2+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)
sABO-B:Mn2+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)
Mn2+ [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)
Mn2+ [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)
Mn2+ [extracellular region]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Metal sequestration by antimicrobial proteins (Gallus gallus)
S100A8:S100A9 binds Mn2+ (Gallus gallus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Gallus gallus)
Mn2+ [extracellular region]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]