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What is Reactome ?
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Table of Contents
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Mn2+ [cytosol]
Stable Identifier
R-ALL-29418
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Manganese, manganese(2+), Mn(II)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Paracetamol ADME (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)
CNDP2:2Mn2+ dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)
CNDP2:2Mn2+ dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of pyrophosphates in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
NUDT(1) [cytosol] (Bos taurus)
NUDT10:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
NUDT(1) [cytosol] (Bos taurus)
NUDT10:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
NUDT(1) [cytosol] (Bos taurus)
NUDT10:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
NUDT(1) [cytosol] (Bos taurus)
NUDT10:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
NUDT4:Mg2+/Mn2+ [cytosol] (Bos taurus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Urea cycle (Bos taurus)
arginine + H2O => ornithine + urea [ARG1] (Bos taurus)
ARG1 trimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Glycogen metabolism (Bos taurus)
Glycogen breakdown (glycogenolysis) (Bos taurus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Bos taurus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Bos taurus)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
glycogen-glycogenin-2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Bos taurus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Bos taurus)
limit dextrin-glycogenin-1 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
GYG2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Bos taurus)
Mn2+ [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Carnitine metabolism (Bos taurus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Btn-ACACA:2Mn2+ polymer [cytosol] (Bos taurus)
Btn-ACACA:2Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Bos taurus)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Bos taurus)
Mn2+ [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Bos taurus)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Bos taurus)
Mn2+ [cytosol]
Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Bos taurus)
Btn-p-S222-ACACB:2Mn2+ [mitochondrial outer membrane] (Bos taurus)
Mn2+ [cytosol]
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
PIK3C2A/3 [cytosol] (Bos taurus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Bos taurus)
PIK3C3:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
PIK3C2A/3 [cytosol] (Bos taurus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Bos taurus)
PIK3C3:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
PIK3C2A/3 [cytosol] (Bos taurus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Bos taurus)
PIK3C3:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Bos taurus)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
ADPRM:Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Biotin transport and metabolism (Bos taurus)
Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)
hCBXs [cytosol] (Bos taurus)
4x(Btn-PC:Mn2+) [cytosol] (Bos taurus)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Bos taurus)
ACACA:2Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Bos taurus)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Bos taurus)
ACACB:2Mn2+ [mitochondrial outer membrane] (Bos taurus)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Bos taurus)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Bos taurus)
4x(Btn-PC:Mn2+) [cytosol] (Bos taurus)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Bos taurus)
Mn2+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Bos taurus)
PP1A(Fe and Mn cofactors) [cytosol] (Bos taurus)
Mn2+ [cytosol]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)
Mn2+ [cytosol]
Drug ADME (Caenorhabditis elegans)
Paracetamol ADME (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
NUDT(1) [cytosol] (Caenorhabditis elegans)
NUDT10:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
NUDT(1) [cytosol] (Caenorhabditis elegans)
NUDT10:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
NUDT(1) [cytosol] (Caenorhabditis elegans)
NUDT10:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
NUDT(1) [cytosol] (Caenorhabditis elegans)
NUDT10:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
NUDT4:Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Urea cycle (Caenorhabditis elegans)
arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)
ARG1 trimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glycogen metabolism (Caenorhabditis elegans)
Glycogen breakdown (glycogenolysis) (Caenorhabditis elegans)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Caenorhabditis elegans)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Caenorhabditis elegans)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Caenorhabditis elegans)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Caenorhabditis elegans)
limit dextrin-glycogenin-1 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Carnitine metabolism (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer [cytosol] (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Caenorhabditis elegans)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Caenorhabditis elegans)
Mn2+ [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
PIK3C3:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
PIK3(2) [cytosol] (Caenorhabditis elegans)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Biotin transport and metabolism (Caenorhabditis elegans)
Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)
hCBXs [cytosol] (Caenorhabditis elegans)
4x(Btn-PC:Mn2+) [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
ACACA:2Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Caenorhabditis elegans)
ACACB:2Mn2+ [mitochondrial outer membrane] (Caenorhabditis elegans)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Caenorhabditis elegans)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
4x(Btn-PC:Mn2+) [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PHLPP dephosphorylates S473 in AKT (Caenorhabditis elegans)
PHLPP (Mn2+ cofactor) [cytosol] (Caenorhabditis elegans)
Mn2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)
Mn2+ [cytosol]
Drug ADME (Canis familiaris)
Paracetamol ADME (Canis familiaris)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)
CNDP2:2Mn2+ dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)
CNDP2:2Mn2+ dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
NUDT(1) [cytosol] (Canis familiaris)
NUDT10:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
NUDT(1) [cytosol] (Canis familiaris)
NUDT10:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
NUDT(1) [cytosol] (Canis familiaris)
NUDT10:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
NUDT(1) [cytosol] (Canis familiaris)
NUDT10:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
NUDT4:Mg2+/Mn2+ [cytosol] (Canis familiaris)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Urea cycle (Canis familiaris)
arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)
ARG1 trimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Glycogen metabolism (Canis familiaris)
Glycogen breakdown (glycogenolysis) (Canis familiaris)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Canis familiaris)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Canis familiaris)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
glycogen-glycogenin-2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Canis familiaris)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Canis familiaris)
limit dextrin-glycogenin-1 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
GYG2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Carnitine metabolism (Canis familiaris)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
Btn-ACACA:2Mn2+ polymer [cytosol] (Canis familiaris)
Btn-ACACA:2Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Canis familiaris)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Canis familiaris)
Mn2+ [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Canis familiaris)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Canis familiaris)
Mn2+ [cytosol]
Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Canis familiaris)
Btn-p-S222-ACACB:2Mn2+ [mitochondrial outer membrane] (Canis familiaris)
Mn2+ [cytosol]
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Canis familiaris)
PIK3C3:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Canis familiaris)
PIK3C3:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Canis familiaris)
PIK3C3:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
ADPRM:Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Biotin transport and metabolism (Canis familiaris)
Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)
hCBXs [cytosol] (Canis familiaris)
4x(Btn-PC:Mn2+) [cytosol] (Canis familiaris)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
ACACA:2Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Canis familiaris)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Canis familiaris)
ACACB:2Mn2+ [mitochondrial outer membrane] (Canis familiaris)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Canis familiaris)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Canis familiaris)
4x(Btn-PC:Mn2+) [cytosol] (Canis familiaris)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PHLPP dephosphorylates S473 in AKT (Canis familiaris)
PHLPP (Mn2+ cofactor) [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Canis familiaris)
PP1A(Fe and Mn cofactors) [cytosol] (Canis familiaris)
Mn2+ [cytosol]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Drug ADME (Danio rerio)
Paracetamol ADME (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)
CNDP2:2Mn2+ dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)
CNDP2:2Mn2+ dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of pyrophosphates in the cytosol (Danio rerio)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
NUDT(1) [cytosol] (Danio rerio)
NUDT10:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
NUDT(1) [cytosol] (Danio rerio)
NUDT10:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
NUDT(1) [cytosol] (Danio rerio)
NUDT10:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
NUDT(1) [cytosol] (Danio rerio)
NUDT10:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
NUDT4:Mg2+/Mn2+ [cytosol] (Danio rerio)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Urea cycle (Danio rerio)
arginine + H2O => ornithine + urea [ARG1] (Danio rerio)
ARG1 trimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glycogen metabolism (Danio rerio)
Glycogen breakdown (glycogenolysis) (Danio rerio)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Danio rerio)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Danio rerio)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
limit dextrin-glycogenin-1 dimer [cytosol] (Danio rerio)
Mn2+ [cytosol]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Carnitine metabolism (Danio rerio)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)
Btn-ACACA:2Mn2+ polymer [cytosol] (Danio rerio)
Btn-ACACA:2Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Danio rerio)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Danio rerio)
Mn2+ [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Danio rerio)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Danio rerio)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Danio rerio)
Mn2+ [cytosol]
Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Danio rerio)
Btn-p-S222-ACACB:2Mn2+ [mitochondrial outer membrane] (Danio rerio)
Mn2+ [cytosol]
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the Golgi membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Danio rerio)
PIK3C3:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Danio rerio)
PIK3C3:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Danio rerio)
PIK3C3:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Danio rerio)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
ADPRM:Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Biotin transport and metabolism (Danio rerio)
Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)
hCBXs [cytosol] (Danio rerio)
4x(Btn-PC:Mn2+) [cytosol] (Danio rerio)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Danio rerio)
ACACA:2Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Danio rerio)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Danio rerio)
ACACB:2Mn2+ [mitochondrial outer membrane] (Danio rerio)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Danio rerio)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Danio rerio)
4x(Btn-PC:Mn2+) [cytosol] (Danio rerio)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Danio rerio)
Mn2+ [cytosol]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PHLPP dephosphorylates S473 in AKT (Danio rerio)
PHLPP (Mn2+ cofactor) [cytosol] (Danio rerio)
Mn2+ [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
DARPP-32 events (Danio rerio)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Danio rerio)
PP1A(Fe and Mn cofactors) [cytosol] (Danio rerio)
Mn2+ [cytosol]
Transport of small molecules (Danio rerio)
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)
Mn2+ [cytosol]
Drug ADME (Dictyostelium discoideum)
Paracetamol ADME (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Antimicrobial peptides (Dictyostelium discoideum)
Ion influx/efflux at host-pathogen interface (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of pyrophosphates in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
NUDT(1) [cytosol] (Dictyostelium discoideum)
NUDT10:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
NUDT(1) [cytosol] (Dictyostelium discoideum)
NUDT10:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
NUDT(1) [cytosol] (Dictyostelium discoideum)
NUDT10:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
NUDT(1) [cytosol] (Dictyostelium discoideum)
NUDT10:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
NUDT4:Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Urea cycle (Dictyostelium discoideum)
arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)
ARG1 trimer [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Fatty acid metabolism (Dictyostelium discoideum)
Carnitine metabolism (Dictyostelium discoideum)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
Btn-ACACA:2Mn2+ polymer [cytosol] (Dictyostelium discoideum)
Btn-ACACA:2Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Dictyostelium discoideum)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Dictyostelium discoideum)
Mn2+ [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Dictyostelium discoideum)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Dictyostelium discoideum)
Mn2+ [cytosol]
Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Dictyostelium discoideum)
Btn-p-S222-ACACB:2Mn2+ [mitochondrial outer membrane] (Dictyostelium discoideum)
Mn2+ [cytosol]
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the Golgi membrane (Dictyostelium discoideum)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Dictyostelium discoideum)
PIK3C2A/3 [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Dictyostelium discoideum)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)
PIK3C2A/3 [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Dictyostelium discoideum)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)
PIK3C2A/3 [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
PIK3C3:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)
PIK3(2) [cytosol] (Dictyostelium discoideum)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Dictyostelium discoideum)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Biotin transport and metabolism (Dictyostelium discoideum)
HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)
ACACA:2Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Dictyostelium discoideum)
ACACB:2Mn2+ [mitochondrial outer membrane] (Dictyostelium discoideum)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Dictyostelium discoideum)
Mn2+ [cytosol]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)
PHLPP (Mn2+ cofactor) [cytosol] (Dictyostelium discoideum)
Mn2+ [cytosol]
Transport of small molecules (Dictyostelium discoideum)
Ion channel transport (Dictyostelium discoideum)
Ion transport by P-type ATPases (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)
Mn2+ [cytosol]
Drug ADME (Drosophila melanogaster)
Paracetamol ADME (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)
CNDP2:2Mn2+ dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Antimicrobial peptides (Drosophila melanogaster)
Ion influx/efflux at host-pathogen interface (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase II - Conjugation of compounds (Drosophila melanogaster)
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)
CNDP2:2Mn2+ dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of pyrophosphates in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
NUDT(1) [cytosol] (Drosophila melanogaster)
NUDT10:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
NUDT(1) [cytosol] (Drosophila melanogaster)
NUDT10:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
NUDT(1) [cytosol] (Drosophila melanogaster)
NUDT10:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
NUDT(1) [cytosol] (Drosophila melanogaster)
NUDT10:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
NUDT4:Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Urea cycle (Drosophila melanogaster)
arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)
ARG1 trimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Glycogen metabolism (Drosophila melanogaster)
Glycogen breakdown (glycogenolysis) (Drosophila melanogaster)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Drosophila melanogaster)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Drosophila melanogaster)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Drosophila melanogaster)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Drosophila melanogaster)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Drosophila melanogaster)
limit dextrin-glycogenin-1 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Fatty acid metabolism (Drosophila melanogaster)
Carnitine metabolism (Drosophila melanogaster)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
Btn-ACACA:2Mn2+ polymer [cytosol] (Drosophila melanogaster)
Btn-ACACA:2Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Drosophila melanogaster)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Drosophila melanogaster)
Mn2+ [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the Golgi membrane (Drosophila melanogaster)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)
PIK3C2A/3 [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Drosophila melanogaster)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)
PIK3C2A/3 [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Drosophila melanogaster)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)
PIK3C2A/3 [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
PIK3C3:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)
PIK3(2) [cytosol] (Drosophila melanogaster)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Drosophila melanogaster)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Biotin transport and metabolism (Drosophila melanogaster)
Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)
hCBXs [cytosol] (Drosophila melanogaster)
4x(Btn-PC:Mn2+) [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)
ACACA:2Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Drosophila melanogaster)
ACACB:2Mn2+ [mitochondrial outer membrane] (Drosophila melanogaster)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Drosophila melanogaster)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)
4x(Btn-PC:Mn2+) [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
PHLPP (Mn2+ cofactor) [cytosol] (Drosophila melanogaster)
Mn2+ [cytosol]
Transport of small molecules (Drosophila melanogaster)
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)
Mn2+ [cytosol]
Drug ADME (Gallus gallus)
Paracetamol ADME (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)
CNDP2:2Mn2+ dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Glutathione conjugation (Gallus gallus)
Glutathione synthesis and recycling (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Gallus gallus)
CNDP2:2Mn2+ dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Inositol phosphate metabolism (Gallus gallus)
Synthesis of pyrophosphates in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
NUDT(1) [cytosol] (Gallus gallus)
NUDT10:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
NUDT(1) [cytosol] (Gallus gallus)
NUDT10:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
NUDT(1) [cytosol] (Gallus gallus)
NUDT10:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
NUDT(1) [cytosol] (Gallus gallus)
NUDT10:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)
NUDT4:Mg2+/Mn2+ [cytosol] (Gallus gallus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Glycogen metabolism (Gallus gallus)
Glycogen breakdown (glycogenolysis) (Gallus gallus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Gallus gallus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Gallus gallus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Gallus gallus)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Gallus gallus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Gallus gallus)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Gallus gallus)
limit dextrin-glycogenin-1 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Carnitine metabolism (Gallus gallus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Gallus gallus)
Btn-ACACA:2Mn2+ polymer [cytosol] (Gallus gallus)
Btn-ACACA:2Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the Golgi membrane (Gallus gallus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Gallus gallus)
PIK3C2A/3 [cytosol] (Gallus gallus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Gallus gallus)
PIK3C3:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Gallus gallus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Gallus gallus)
PIK3C2A/3 [cytosol] (Gallus gallus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Gallus gallus)
PIK3C3:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Gallus gallus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Gallus gallus)
PIK3C2A/3 [cytosol] (Gallus gallus)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Gallus gallus)
PIK3C3:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Gallus gallus)
PIK3(2) [cytosol] (Gallus gallus)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Gallus gallus)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of nucleotides (Gallus gallus)
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
ADPRM:Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Biotin transport and metabolism (Gallus gallus)
HLCS biotinylates ACACA:Mn2+ (Gallus gallus)
ACACA:2Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
PHLPP (Mn2+ cofactor) [cytosol] (Gallus gallus)
Mn2+ [cytosol]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in biotin (Btn) metabolism (Homo sapiens)
Defective HLCS causes multiple carboxylase deficiency (Homo sapiens)
Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)
4x(PC:Mn2+) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS coronavirus 2 gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)
SARS coronavirus 2 gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-capped SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp15 cleaves viral poly(U)-RNA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS coronavirus gRNA with secondary structure:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS coronavirus 2 gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-capped SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp8 generates RNA primers (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)
SARS-CoV-2 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) (Homo sapiens)
nsp16 binds nsp10 (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)
CNBP:SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
SARS-CoV-2 dsRNA intermediates:DDX58 [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
SARS-CoV-2 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
LARP1 binds SARS-CoV-2 RNA (Homo sapiens)
LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp16:nsp10 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Drug ADME (Homo sapiens)
Paracetamol ADME (Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)
CNDP2:2Mn2+ dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)
CNDP2:2Mn2+ dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Inositol phosphate metabolism (Homo sapiens)
Synthesis of pyrophosphates in the cytosol (Homo sapiens)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
NUDT(1) [cytosol] (Homo sapiens)
NUDT10:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT11:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
NUDT(1) [cytosol] (Homo sapiens)
NUDT10:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT11:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
NUDT(1) [cytosol] (Homo sapiens)
NUDT10:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT11:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
NUDT(1) [cytosol] (Homo sapiens)
NUDT10:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT11:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)
NUDT4:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Urea cycle (Homo sapiens)
arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)
ARG1 trimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen breakdown (glycogenolysis) (Homo sapiens)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Homo sapiens)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Homo sapiens)
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
glycogen-glycogenin-1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
limit dextrin-glycogenin-1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
glycogen-glycogenin-2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer [cytosol] (Homo sapiens)
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
limit dextrin-glycogenin dimer [cytosol] (Homo sapiens)
limit dextrin-glycogenin-1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
limit dextrin-glycogenin-2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
GYG2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG2 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
GYG1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine metabolism (Homo sapiens)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Btn-ACACA:2Mn2+ polymer [cytosol] (Homo sapiens)
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Homo sapiens)
Btn-p-S222-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Homo sapiens)
Ca2+/Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
ADPRM:Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
An unknown protease degrades ACACA (Homo sapiens)
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
An unknown protease degrades ACACB (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)
hCBXs [cytosol] (Homo sapiens)
4x(Btn-PC:Mn2+) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Mn2+ [cytosol]
HLCS biotinylates ACACB (Homo sapiens)
ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Mn2+ [cytosol]
HLCS biotinylates PC:Mn2+ (Homo sapiens)
4x(Btn-PC:Mn2+) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
4x(PC:Mn2+) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PHLPP dephosphorylates S473 in AKT (Homo sapiens)
PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Homo sapiens)
PP1A(Fe and Mn cofactors) [cytosol] (Homo sapiens)
Mn2+ [cytosol]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)
Mn2+ [cytosol]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)
Mn2+ [cytosol]
Drug ADME (Mus musculus)
Paracetamol ADME (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)
CNDP2:2Mn2+ dimer [cytosol] (Mus musculus)
Mn2+ [cytosol]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Ion influx/efflux at host-pathogen interface (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
ROS and RNS production in phagocytes (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
Divalent metals transported by NRAMP1 [cytosol]
Mn2+ [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Glutathione conjugation (Mus musculus)
Glutathione synthesis and recycling (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)
CNDP2:2Mn2+ dimer [cytosol] (Mus musculus)
Mn2+ [cytosol]
Inositol phosphate metabolism (Mus musculus)
Synthesis of pyrophosphates in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
NUDT(1) [cytosol] (Mus musculus)
NUDT10:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
NUDT(1) [cytosol] (Mus musculus)
NUDT10:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
NUDT(1) [cytosol] (Mus musculus)
NUDT10:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
NUDT4:Mg2+/Mn2+ [cytosol] (Mus musculus)
Mg2+/Mn2+ [cytosol]
Mn2+ [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)