Reactome | S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]

Stable Identifier

R-HSA-6798411

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Synonyms

calprotectin heterotetramer

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25597447	Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis	J. Am. Chem. Soc.	2015
23431180	Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens	Proc. Natl. Acad. Sci. U.S.A.	2013
17553524	The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins	J. Mol. Biol.	2007

Participants

components

Participant Of

output

Inferred To