S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]

Stable Identifier
R-HSA-6798411
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
calprotectin heterotetramer
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25597447 Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis

Gagnon, DM, Brophy, MB, Bowman, SE, Stich, TA, Drennan, CL, Britt, RD, Nolan, EM

J. Am. Chem. Soc. 2015
23431180 Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

Damo, SM, Kehl-Fie, TE, Sugitani, N, Holt, ME, Rathi, S, Murphy, WJ, Zhang, Y, Betz, C, Hench, L, Fritz, G, Skaar, EP, Chazin, WJ

Proc. Natl. Acad. Sci. U.S.A. 2013
17553524 The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins

Korndörfer, IP, Brueckner, F, Skerra, A

J. Mol. Biol. 2007
Participants
components
Participant Of
output
Inferred To
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Canis familiaris)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Danio rerio)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Gallus gallus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Mus musculus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Rattus norvegicus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Sus scrofa)