S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]

Stable Identifier
R-HSA-6798411
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
calprotectin heterotetramer
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25597447 Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis

Nolan, EM, Brophy, MB, Drennan, CL, Gagnon, DM, Britt, RD, Stich, TA, Bowman, SE

J. Am. Chem. Soc. 2015
17553524 The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins

Skerra, A, Brueckner, F, Korndörfer, IP

J. Mol. Biol. 2007
23431180 Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

Hench, L, Skaar, EP, Sugitani, N, Fritz, G, Betz, C, Zhang, Y, Rathi, S, Damo, SM, Kehl-Fie, TE, Chazin, WJ, Murphy, WJ, Holt, ME

Proc. Natl. Acad. Sci. U.S.A. 2013
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