Reactome | 26S proteasome degrades HIFalpha

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26S proteasome degrades HIFalpha Show undefined attributes

catalystActivity	[CatalystActivity:10652009] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723850
displayName	26S proteasome degrades HIFalpha
eventOf	[Pathway:R-XTR-8951664] Neddylation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9755303] 26S proteasome degrades HIFalpha - Homo sapiens
input	[Complex:R-XTR-8956079] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	26S proteasome degrades HIFalpha
output	[Complex:R-XTR-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [DefinedSet:R-XTR-113595] Ub [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9755303
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8951664] Neddylation
(inferredTo)	[BlackBoxEvent:R-HSA-9755303] 26S proteasome degrades HIFalpha

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