Reactome | 26S proteasome degrades HIFalpha

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26S proteasome degrades HIFalpha Show undefined attributes

authored	[InstanceEdit:9761879] Rothfels, Karen, 2022-01-16
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755309] Rothfels, Karen, 2021-10-07
dbId	9755303
displayName	26S proteasome degrades HIFalpha
edited	[InstanceEdit:9761879] Rothfels, Karen, 2022-01-16
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input	[Complex:R-HSA-8956079] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1234014] Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm [LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:392092] Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation [LiteratureReference:1233947] HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	26S proteasome degrades HIFalpha
negativePrecedingEvent	[NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent	[BlackBoxEvent:R-CEL-9755303] 26S proteasome degrades HIFalpha - Caenorhabditis elegans [BlackBoxEvent:R-DME-9755303] 26S proteasome degrades HIFalpha - Drosophila melanogaster [BlackBoxEvent:R-GGA-9755303] 26S proteasome degrades HIFalpha - Gallus gallus [BlackBoxEvent:R-XTR-9755303] 26S proteasome degrades HIFalpha - Xenopus tropicalis [BlackBoxEvent:R-DRE-9755303] 26S proteasome degrades HIFalpha - Danio rerio [BlackBoxEvent:R-SSC-9755303] 26S proteasome degrades HIFalpha - Sus scrofa [BlackBoxEvent:R-BTA-9755303] 26S proteasome degrades HIFalpha - Bos taurus [BlackBoxEvent:R-CFA-9755303] 26S proteasome degrades HIFalpha - Canis familiaris [BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha - Rattus norvegicus [BlackBoxEvent:R-MMU-9755303] 26S proteasome degrades HIFalpha - Mus musculus
output	[Complex:R-HSA-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9768153] Somers, Julia, 2022-03-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9755303
summation	[Summation:1235016] Destruction of ubiquitinated HIF-alpha can occur in both the...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[NegativePrecedingEvent:9767172] Futile Cycle: 26S proteasome degrades HIFalpha [NegativePrecedingEvent:9767170] Futile Cycle: 26S proteasome degrades HIFalpha

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