Reactome | RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-8956077] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 - Xenopus tropicalis [Reaction:R-XTR-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10718389
displayName	RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
hasComponent	[Complex:R-XTR-8955646] COMMDs:CCDC22 [cytosol] [EntityWithAccessionedSequence:R-XTR-8952511] cul2 [cytosol] [CandidateSet:R-XTR-8952547] DCUN1D1,2,4,5 [cytosol] [EntityWithAccessionedSequence:R-XTR-180582] rbx1 [cytosol] [Complex:R-XTR-390483] VBC complex [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] - Homo sapiens
maxDepth	4
name	RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5
producedByEvent	[BlackBoxEvent:R-XTR-9755303] 26S proteasome degrades HIFalpha - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8956074
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-XTR-8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 [Reaction:R-XTR-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
(output)	[BlackBoxEvent:R-XTR-9755303] 26S proteasome degrades HIFalpha
(hasComponent)	[Complex:R-XTR-8956077] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] [Complex:R-XTR-8956079] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [Complex:R-XTR-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
(inferredTo)	[Complex:R-HSA-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]