Reactome | Cyclin D associated events in G1

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Cyclin D associated events in G1 Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728398
displayName	Cyclin D associated events in G1
eventOf	[Pathway:R-XTR-69236] G1 Phase - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-182594] Association of INK4 family proteins with CDK4/6 - Xenopus tropicalis [Reaction:R-XTR-8941895] Formation of CDK4/6:CCND complexes - Xenopus tropicalis [Reaction:R-XTR-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Xenopus tropicalis [Reaction:R-XTR-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Xenopus tropicalis [BlackBoxEvent:R-XTR-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Xenopus tropicalis [Reaction:R-XTR-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Xenopus tropicalis [BlackBoxEvent:R-XTR-9659820] RB1 translocates to the nucleus - Xenopus tropicalis [Reaction:R-XTR-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Xenopus tropicalis [Reaction:R-XTR-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Xenopus tropicalis [Reaction:R-XTR-1226095] Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex - Xenopus tropicalis [Reaction:R-XTR-1363274] Dephosphorylation of p107 (RBL1) by PP2A - Xenopus tropicalis [Reaction:R-XTR-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Xenopus tropicalis [Reaction:R-XTR-1363276] Dephosphorylation of p130 (RBL2) by PP2A - Xenopus tropicalis [Pathway:R-XTR-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cyclin D associated events in G1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-69231
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-69236] G1 Phase
(inferredTo)	[Pathway:R-HSA-69231] Cyclin D associated events in G1

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