Reactome | Association of INK4 family proteins with CDK4/6

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Association of INK4 family proteins with CDK4/6 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10662782
displayName	Association of INK4 family proteins with CDK4/6
eventOf	[Pathway:R-XTR-69231] Cyclin D associated events in G1 - Xenopus tropicalis [Pathway:R-XTR-2559585] Oncogene Induced Senescence - Xenopus tropicalis [Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP) - Xenopus tropicalis [Pathway:R-XTR-2559580] Oxidative Stress Induced Senescence - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1043034] negative regulation of G1/S transition of mitotic cell cycle
inferredFrom	[Reaction:R-HSA-182594] Association of INK4 family proteins with CDK4/6 - Homo sapiens
input	[DefinedSet:R-XTR-69209] CDK4,CDK6 [cytosol] [DefinedSet:R-XTR-182588] INK4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of INK4 family proteins with CDK4/6
output	[Complex:R-XTR-182579] CDK4,CDK6:INK4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-182594
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2559585] Oncogene Induced Senescence [Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-XTR-2559580] Oxidative Stress Induced Senescence [Pathway:R-XTR-69231] Cyclin D associated events in G1
(inferredTo)	[Reaction:R-HSA-182594] Association of INK4 family proteins with CDK4/6