Reactome | CDK12 phosphorylates RNA Pol II CTD at DNA repair genes

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CDK12 phosphorylates RNA Pol II CTD at DNA repair genes Show undefined attributes

catalystActivity	[CatalystActivity:10706605] cyclin-dependent protein serine/threonine kinase activity of CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10706607
displayName	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
eventOf	[Pathway:R-XTR-6796648] TP53 Regulates Transcription of DNA Repair Genes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-XTR-6797614] CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-XTR-6797602] CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm]
precedingEvent	[Reaction:R-XTR-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6797606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6796648] TP53 Regulates Transcription of DNA Repair Genes
(inferredTo)	[Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes

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