Reactome | POLQ homodimer [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10702578
displayName	POLQ homodimer [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-XTR-5687494] polq [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5687515] POLQ homodimer [nucleoplasm] - Homo sapiens
maxDepth	2
name	POLQ homodimer
producedByEvent	[Reaction:R-XTR-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5687515
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-XTR-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
(activeUnit)	[CatalystActivity:10702593] DNA-directed DNA polymerase activity of Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(input)	[Reaction:R-XTR-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
(hasComponent)	[Complex:R-XTR-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Complex:R-XTR-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5687515] POLQ homodimer [nucleoplasm]