Reactome | Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10702602] NAD+ poly-ADP-ribosyltransferase activity of Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-XTR-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10702592
displayName	Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
hasComponent	[Complex:R-XTR-5687644] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-54745] FEN1 [nucleoplasm] [Complex:R-XTR-5649884] PARP1,PARP2 dimers [nucleoplasm] [Complex:R-XTR-5687515] POLQ homodimer [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Homo sapiens
maxDepth	5
name	Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ
producedByEvent	[Reaction:R-XTR-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5687643
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-XTR-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
(physicalEntity)	[CatalystActivity:10702602] NAD+ poly-ADP-ribosyltransferase activity of Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(output)	[Reaction:R-XTR-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ
(inferredTo)	[Complex:R-HSA-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]

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