Reactome | POLQ homodimer [nucleoplasm]

Schema > Complex > Entries

POLQ homodimer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Homo sapiens [Complex:R-HSA-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Homo sapiens
created	[InstanceEdit:5687505] Orlic-Milacic, Marija, 2015-04-08
dbId	5687515
displayName	POLQ homodimer [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-5687494] POLQ [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-5687515] POLQ homodimer [nucleoplasm] - Mus musculus [Complex:R-RNO-5687515] POLQ homodimer [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5687515] POLQ homodimer [nucleoplasm] - Canis familiaris [Complex:R-BTA-5687515] POLQ homodimer [nucleoplasm] - Bos taurus [Complex:R-SSC-5687515] POLQ homodimer [nucleoplasm] - Sus scrofa [Complex:R-DRE-5687515] POLQ homodimer [nucleoplasm] - Danio rerio [Complex:R-XTR-5687515] POLQ homodimer [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-5687515] POLQ homodimer [nucleoplasm] - Gallus gallus [Complex:R-DME-5687515] POLQ homodimer [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-5687515] POLQ homodimer [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:5687501] Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?
maxDepth	2
name	POLQ homodimer
producedByEvent	[Reaction:R-HSA-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5687515

Referrals

(input)	[Reaction:R-HSA-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
(hasComponent)	[Complex:R-HSA-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Complex:R-HSA-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(activeUnit)	[CatalystActivity:5687641] DNA-directed DNA polymerase activity of Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(output)	[Reaction:R-HSA-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate

© 2026 Reactome

Cite Us!