Reactome | PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site

Schema > Reaction > Entries

PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10702586
displayName	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
eventOf	[Pathway:R-XTR-5685939] HDR through MMEJ (alt-NHEJ) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-54745] FEN1 [nucleoplasm] [Complex:R-XTR-5687460] Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] [Complex:R-XTR-5649884] PARP1,PARP2 dimers [nucleoplasm] [Complex:R-XTR-5687515] POLQ homodimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
output	[Complex:R-XTR-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
precedingEvent	[Reaction:R-XTR-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5687484
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5685939] HDR through MMEJ (alt-NHEJ)
(precedingEvent)	[Reaction:R-XTR-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ
(inferredTo)	[Reaction:R-HSA-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site

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