Reactome | NUMB binds ITCH

Schema > Reaction > Entries

NUMB binds ITCH Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10698575
displayName	NUMB binds ITCH
eventOf	[Pathway:R-XTR-5610780] Degradation of GLI1 by the proteasome - Xenopus tropicalis [Pathway:R-XTR-5632684] Hedgehog 'on' state - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-5610737] NUMB:ITCH bind and ubiquitnate GLI1 - Xenopus tropicalis [Reaction:R-XTR-5635861] NUMB:ITCH binds GLI1 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-975995] itch [cytosol] [EntityWithAccessionedSequence:R-XTR-443595] numb [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NUMB binds ITCH
output	[Complex:R-XTR-5610562] NUMB:ITCH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5610735
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5610780] Degradation of GLI1 by the proteasome [Pathway:R-XTR-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-XTR-5610737] NUMB:ITCH bind and ubiquitnate GLI1 [Reaction:R-XTR-5635861] NUMB:ITCH binds GLI1
(inferredTo)	[Reaction:R-HSA-5610735] NUMB binds ITCH