Reactome | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

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Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730734
displayName	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
eventOf	[Pathway:R-XTR-5358508] Mismatch Repair - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17157] mismatch repair
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-5444516] Formation of MSH2:MSH6 Complex - Xenopus tropicalis [Reaction:R-XTR-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Xenopus tropicalis [Reaction:R-XTR-5358912] MSH2:MSH6 exchanges ADP for ATP - Xenopus tropicalis [Reaction:R-XTR-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5358565
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5358508] Mismatch Repair
(inferredTo)	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

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