Reactome | LTA4 is converted to LTC4 by LTC4S

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LTA4 is converted to LTC4 by LTC4S Show undefined attributes

catalystActivity	[CatalystActivity:10667995] leukotriene-C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10667997
displayName	LTA4 is converted to LTC4 by LTC4S
eventOf	[Pathway:R-XTR-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-266070] LTC4 is exported from the cytosol by ABCC1 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-266050] LTA4 is converted to LTC4 by LTC4S - Homo sapiens
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-265281] LTA4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LTA4 is converted to LTC4 by LTC4S glutathione + leukotriene A4 => leukotriene C4 LTA4 conjugates with glutathione to form LTC4
output	[SimpleEntity:R-ALL-266066] LTC4 [cytosol]
precedingEvent	[Reaction:R-XTR-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-266050
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-XTR-266070] LTC4 is exported from the cytosol by ABCC1
(inferredTo)	[Reaction:R-HSA-266050] LTA4 is converted to LTC4 by LTC4S

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