Reactome | Synthesis of Leukotrienes (LT) and Eoxins (EX)

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Synthesis of Leukotrienes (LT) and Eoxins (EX) Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729630
displayName	Synthesis of Leukotrienes (LT) and Eoxins (EX)
eventOf	[Pathway:R-XTR-2142753] Arachidonate metabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9962] leukotriene metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Xenopus tropicalis [Reaction:R-XTR-9707186] ALOX5 binds ALOX5 inhibitors - Xenopus tropicalis [Reaction:R-XTR-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Xenopus tropicalis [Reaction:R-XTR-266072] LTA4 is hydolysed to LTB4 by LTA4H - Xenopus tropicalis [Reaction:R-XTR-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Xenopus tropicalis [Reaction:R-XTR-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Xenopus tropicalis [Reaction:R-XTR-2161792] 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 - Xenopus tropicalis [Reaction:R-XTR-266050] LTA4 is converted to LTC4 by LTC4S - Xenopus tropicalis [Reaction:R-XTR-266070] LTC4 is exported from the cytosol by ABCC1 - Xenopus tropicalis [Reaction:R-XTR-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4 - Xenopus tropicalis [Reaction:R-XTR-2161768] EXA4 is converted to EXC4 by LTC4S - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of Leukotrienes (LT) and Eoxins (EX)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2142691
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142753] Arachidonate metabolism
(inferredTo)	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)

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