Reactome | LTC4 is exported from the cytosol by ABCC1

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LTC4 is exported from the cytosol by ABCC1 Show undefined attributes

catalystActivity	[CatalystActivity:10668004] ABC-type transporter activity of ABCC1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10668006
displayName	LTC4 is exported from the cytosol by ABCC1
eventOf	[Pathway:R-XTR-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-266070] LTC4 is exported from the cytosol by ABCC1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-266066] LTC4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LTC4 is exported from the cytosol by ABCC1 ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate ABCC1 mediates LTC4 export from the cell
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-266013] LTC4 [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-XTR-266050] LTA4 is converted to LTC4 by LTC4S - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-266070
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-XTR-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4
(inferredTo)	[Reaction:R-HSA-266070] LTC4 is exported from the cytosol by ABCC1

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