Reactome | LTA4 is converted to LTC4 by LTC4S

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LTA4 is converted to LTC4 by LTC4S Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:266055] leukotriene-C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:266031] Jassal, B, 2008-04-21 14:30:43
crossReference	[DatabaseIdentifier:12668270] RHEA:17619 [DatabaseIdentifier:9915862] RHEA:17619
dbId	266050
displayName	LTA4 is converted to LTC4 by LTC4S
edited	[InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22
eventOf	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
followingEvent	[Reaction:R-HSA-266070] LTC4 is exported from the cytosol by ABCC1 - Homo sapiens
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-265281] LTA4 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:266053] Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4 [LiteratureReference:266019] Molecular cloning and expression of human leukotriene-C4 synthase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	LTA4 is converted to LTC4 by LTC4S glutathione + leukotriene A4 => leukotriene C4 LTA4 conjugates with glutathione to form LTC4
orthologousEvent	[Reaction:R-DDI-266050] LTA4 is converted to LTC4 by LTC4S - Dictyostelium discoideum [Reaction:R-GGA-266050] LTA4 is converted to LTC4 by LTC4S - Gallus gallus [Reaction:R-XTR-266050] LTA4 is converted to LTC4 by LTC4S - Xenopus tropicalis [Reaction:R-DRE-266050] LTA4 is converted to LTC4 by LTC4S - Danio rerio [Reaction:R-SSC-266050] LTA4 is converted to LTC4 by LTC4S - Sus scrofa [Reaction:R-BTA-266050] LTA4 is converted to LTC4 by LTC4S - Bos taurus [Reaction:R-RNO-266050] LTA4 is converted to LTC4 by LTC4S - Rattus norvegicus [Reaction:R-MMU-266050] LTA4 is converted to LTC4 by LTC4S - Mus musculus
output	[SimpleEntity:R-ALL-266066] LTC4 [cytosol]
precedingEvent	[Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-266050
summation	[Summation:266015] Leukotriene A4 conjugates with reduced glutathione (GSH) to ...
updateTrackers	[UpdateTracker:9788683] Update Tracker - [Reaction:266050] LTA4 is converted to LTC4 by LTC4S - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788683] Update Tracker - [Reaction:266050] LTA4 is converted to LTC4 by LTC4S - v41:[modifyText]
(hasEvent)	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-HSA-266070] LTC4 is exported from the cytosol by ABCC1

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