Reactome | pten [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10684973] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10665129] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-8847960] PTEN:p-Y387-FRK [cytosol] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-8948775] MKRN1 polyubiquitinates PTEN - Xenopus tropicalis [Reaction:R-XTR-8850997] TRIM27 binds PTEN - Xenopus tropicalis [Reaction:R-XTR-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Xenopus tropicalis [Reaction:R-XTR-8847968] PTEN binds FRK - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10665128
displayName	pten [cytosol]
endCoordinate	403
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-XTR-8850937] PTEN, p-3S,2T-PTEN [cytosol] - Xenopus tropicalis
name	pten PTEN B1H2U0
producedByEvent	[Reaction:R-XTR-8873946] OTUD3 deubiquitinates PTEN - Xenopus tropicalis [Reaction:R-XTR-6807206] USP13 and OTUD3 deubiquitinate PTEN - Xenopus tropicalis [Reaction:R-XTR-6807126] Deubiquitinated PTEN translocates to the cytosol - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:B1H2U0] UniProt:B1H2U0
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-199420
startCoordinate	2

(output)	[Reaction:R-XTR-8873946] OTUD3 deubiquitinates PTEN [Reaction:R-XTR-6807206] USP13 and OTUD3 deubiquitinate PTEN [Reaction:R-XTR-6807126] Deubiquitinated PTEN translocates to the cytosol
(hasMember)	[DefinedSet:R-XTR-8850937] PTEN, p-3S,2T-PTEN [cytosol]
(input)	[Reaction:R-XTR-8948775] MKRN1 polyubiquitinates PTEN [Reaction:R-XTR-8847968] PTEN binds FRK [Reaction:R-XTR-8850997] TRIM27 binds PTEN [Reaction:R-XTR-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
(hasComponent)	[Complex:R-XTR-8847960] PTEN:p-Y387-FRK [cytosol] [Complex:R-XTR-8851000] PTEN:TRIM27 [cytosol] [Complex:R-XTR-199426] PTEN:Mg2+ [cytosol]
(physicalEntity)	[CatalystActivity:10684973] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10665129] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]