Reactome | USP13 and OTUD3 deubiquitinate PTEN

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USP13 and OTUD3 deubiquitinate PTEN Show undefined attributes

catalystActivity	[CatalystActivity:10710358] cysteine-type deubiquitinase activity of USP13,OTUD3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10710360
displayName	USP13 and OTUD3 deubiquitinate PTEN
eventOf	[Pathway:R-XTR-8948751] Regulation of PTEN stability and activity - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6807206] USP13 and OTUD3 deubiquitinate PTEN - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-XTR-8948777] pten [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	USP13 and OTUD3 deubiquitinate PTEN
output	[EntityWithAccessionedSequence:R-XTR-199420] pten [cytosol] 3 × [DefinedSet:R-XTR-113595] Ub [cytosol]
precedingEvent	[Reaction:R-XTR-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6807206
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8948751] Regulation of PTEN stability and activity
(inferredTo)	[Reaction:R-HSA-6807206] USP13 and OTUD3 deubiquitinate PTEN

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