Reactome | OTUD3 deubiquitinates PTEN

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10710358] cysteine-type deubiquitinase activity of USP13,OTUD3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10714851
displayName	OTUD3 deubiquitinates PTEN
eventOf	[Pathway:R-XTR-5689896] Ovarian tumor domain proteases - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8873946] OTUD3 deubiquitinates PTEN - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-8874327] pten [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	OTUD3 deubiquitinates PTEN
output	[EntityWithAccessionedSequence:R-XTR-199420] pten [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8873946
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-5689896] Ovarian tumor domain proteases
(inferredTo)	[Reaction:R-HSA-8873946] OTUD3 deubiquitinates PTEN

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