Reactome | PTPN11 [cytosol]

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PTPN11 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10683375] protein tyrosine phosphatase activity of PTPN11 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-8987132] IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:PTPN11:IL10RB:p?TYK2 binds PTPN11 - Xenopus tropicalis [Reaction:R-XTR-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Xenopus tropicalis [Reaction:R-XTR-8865994] GAB1 binds PTPN11 - Xenopus tropicalis [Reaction:R-XTR-205238] SHP2 interacts with p-KIT - Xenopus tropicalis [Reaction:R-XTR-204873] Interaction of Tie2 and Shp2 - Xenopus tropicalis [Reaction:R-XTR-186778] SHP2 binds to the active receptor - Xenopus tropicalis [Reaction:R-XTR-388829] SHP2 phosphatase binds CTLA-4 - Xenopus tropicalis [Reaction:R-XTR-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Xenopus tropicalis [Reaction:R-XTR-1112708] PTPN11 binds p-Y759-IL6ST - Xenopus tropicalis [Reaction:R-XTR-5654608] Activated FGFR2:p-FRS bind to PPTN11 - Xenopus tropicalis [Reaction:R-XTR-177944] Activation of SHP2 through the binding to phospho-Gab1 - Xenopus tropicalis [Reaction:R-XTR-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Xenopus tropicalis [Reaction:R-XTR-5654633] Activated FGFR3:p-FRS bind to PPTN11 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10662573
displayName	PTPN11 [cytosol]
endCoordinate	593
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-XTR-389744] PTPN6,PTPN11 [cytosol] - Xenopus tropicalis
name	PTPN11 A0A6I8SAV8
referenceEntity	[ReferenceGeneProduct:uniprot:A0A6I8SAV8] UniProt:A0A6I8SAV8
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-162563
startCoordinate	1

Referrals

(input)	[Reaction:R-XTR-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 [Reaction:R-XTR-8865994] GAB1 binds PTPN11 [Reaction:R-XTR-205238] SHP2 interacts with p-KIT [Reaction:R-XTR-204873] Interaction of Tie2 and Shp2 [Reaction:R-XTR-186778] SHP2 binds to the active receptor [Reaction:R-XTR-388829] SHP2 phosphatase binds CTLA-4 [Reaction:R-XTR-8987132] IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:PTPN11:IL10RB:p?TYK2 binds PTPN11 [Reaction:R-XTR-5654584] Activated FGFR1:p-FRS bind to PPTN11 [Reaction:R-XTR-1112708] PTPN11 binds p-Y759-IL6ST [Reaction:R-XTR-5654608] Activated FGFR2:p-FRS bind to PPTN11 [Reaction:R-XTR-177944] Activation of SHP2 through the binding to phospho-Gab1 [Reaction:R-XTR-5654658] Activated FGFR4:p-FRS bind to PPTN11 [Reaction:R-XTR-5654633] Activated FGFR3:p-FRS bind to PPTN11
(hasComponent)	[Complex:R-XTR-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] [Complex:R-XTR-8865998] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] [Complex:R-XTR-205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Complex:R-XTR-204767] pTie2 and SHP2 complex [plasma membrane] [Complex:R-XTR-186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] [Complex:R-XTR-388793] pCTLA-4:Src kinases:SHP2 [plasma membrane] [Complex:R-XTR-8987108] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] [Complex:R-XTR-5654268] Activated FGFR1:p-FRS:PTPN11 [plasma membrane] [Complex:R-XTR-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] [Complex:R-XTR-5654290] Activated FGFR2:p-FRS:PTPN11 [plasma membrane] [Complex:R-XTR-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] [Complex:R-XTR-180326] EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Complex:R-XTR-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Complex:R-XTR-5654337] Activated FGFR4:p-FRS:PTPN11 [plasma membrane] [Complex:R-XTR-5654310] Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
(physicalEntity)	[CatalystActivity:10683375] protein tyrosine phosphatase activity of PTPN11 [cytosol]
(activeUnit)	[CatalystActivity:10662611] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
(hasMember)	[DefinedSet:R-XTR-389744] PTPN6,PTPN11 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]

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