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PTPN11 [cytosol]
Stable Identifier
R-XTR-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
A0A6I8SAV8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
RET signaling (Xenopus tropicalis)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Hemostasis (Xenopus tropicalis)
Cell surface interactions at the vascular wall (Xenopus tropicalis)
Tie2 Signaling (Xenopus tropicalis)
Interaction of Tie2 and Shp2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
pTie2 and SHP2 complex [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Costimulation by the CD28 family (Xenopus tropicalis)
CTLA4 inhibitory signaling (Xenopus tropicalis)
SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
Interferon Signaling (Xenopus tropicalis)
Interferon alpha/beta signaling (Xenopus tropicalis)
Regulation of IFNA/IFNB signaling (Xenopus tropicalis)
Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by Interleukins (Xenopus tropicalis)
Interleukin-20 family signaling (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Xenopus tropicalis)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Interleukin-6 family signaling (Xenopus tropicalis)
Interleukin-6 signaling (Xenopus tropicalis)
PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 is phosphorylated (Xenopus tropicalis)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by EGFR (Xenopus tropicalis)
GAB1 signalosome (Xenopus tropicalis)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by FGFR (Xenopus tropicalis)
Signaling by FGFR1 (Xenopus tropicalis)
Downstream signaling of activated FGFR1 (Xenopus tropicalis)
FRS-mediated FGFR1 signaling (Xenopus tropicalis)
Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Negative regulation of FGFR1 signaling (Xenopus tropicalis)
Spry regulation of FGF signaling (Xenopus tropicalis)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by FGFR2 (Xenopus tropicalis)
Downstream signaling of activated FGFR2 (Xenopus tropicalis)
FRS-mediated FGFR2 signaling (Xenopus tropicalis)
Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Negative regulation of FGFR2 signaling (Xenopus tropicalis)
Spry regulation of FGF signaling (Xenopus tropicalis)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by FGFR3 (Xenopus tropicalis)
Downstream signaling of activated FGFR3 (Xenopus tropicalis)
FRS-mediated FGFR3 signaling (Xenopus tropicalis)
Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Negative regulation of FGFR3 signaling (Xenopus tropicalis)
Spry regulation of FGF signaling (Xenopus tropicalis)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by FGFR4 (Xenopus tropicalis)
Downstream signaling of activated FGFR4 (Xenopus tropicalis)
FRS-mediated FGFR4 signaling (Xenopus tropicalis)
Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Negative regulation of FGFR4 signaling (Xenopus tropicalis)
Spry regulation of FGF signaling (Xenopus tropicalis)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by MET (Xenopus tropicalis)
MET activates PTPN11 (Xenopus tropicalis)
GAB1 binds PTPN11 (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
SHP2 binds to the active receptor (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
Signaling by SCF-KIT (Xenopus tropicalis)
Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
SHP2 interacts with p-KIT (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
PTPN11 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A6I8SAV8
Reference Genes
BioGPS Gene:549586
ENSEMBL:ENSXETG00000004305
Monarch:549586
NCBI Gene:549586
Reference Transcript
RefSeq:XM_012962883.3
Other Identifiers
549586
GO:0003824
GO:0004721
GO:0004725
GO:0005737
GO:0016311
GO:0016787
GO:0071310
GO:0140096
Participates
as an input of
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)
Interaction of Tie2 and Shp2 (Xenopus tropicalis)
SHP2 interacts with p-KIT (Xenopus tropicalis)
PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)
SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
GAB1 binds PTPN11 (Xenopus tropicalis)
Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
SHP2 binds to the active receptor (Xenopus tropicalis)
Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)
as a component of
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Xenopus tropicalis)
pTie2 and SHP2 complex [plasma membrane] (Xenopus tropicalis)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Xenopus tropicalis)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Xenopus tropicalis)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Xenopus tropicalis)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Xenopus tropicalis)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-p-Y542,Y580-PTPN11 [cytosol]
Inferred From
PTPN6,PTPN11 [cytosol]
(Homo sapiens)
PTPN11 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_012818337.1
Xenbase
XB-GENE-22063677
Ensembl
ENSXETG00000004305
,
ENSXETT00000095475
,
ENSXETP00000091934
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