Reactome | TRAF6 [cytosol]

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TRAF6 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-1248657] TRAF6 E3/E2 ubiquitin ligase complex [cytosol] - Sus scrofa [Complex:R-SSC-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] - Sus scrofa [Complex:R-SSC-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] - Sus scrofa [Complex:R-SSC-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] - Sus scrofa [Complex:R-SSC-197481] NF-kB:p75NTR ICD:TRAF6 [cytosol] - Sus scrofa [Complex:R-SSC-8981951] IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-936963] IRAK2 induces TRAF6 oligomerization - Sus scrofa [Reaction:R-SSC-936963] IRAK2 induces TRAF6 oligomerization - Sus scrofa [Reaction:R-SSC-936985] Activated TLR4:TICAM1 recruits TRAF6 - Sus scrofa [Reaction:R-SSC-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Sus scrofa [Reaction:R-SSC-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Sus scrofa [Polymerisation:R-SSC-5607751] TRAF6 oligomerizes - Sus scrofa [Polymerisation:R-SSC-5607751] TRAF6 oligomerizes - Sus scrofa [Reaction:R-SSC-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Sus scrofa [Reaction:R-SSC-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Sus scrofa [Reaction:R-SSC-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Sus scrofa [Reaction:R-SSC-166869] TRAF6 binds MEKK1 - Sus scrofa [Reaction:R-SSC-2730864] Recruitment of TRAF6 to CBM complex by binding to MALT1 - Sus scrofa [BlackBoxEvent:R-SSC-2730903] Oligomerization of TRAF6 - Sus scrofa [Reaction:R-SSC-202472] Translocation of TRAF6 to CBM complex - Sus scrofa [Reaction:R-SSC-202472] Translocation of TRAF6 to CBM complex - Sus scrofa [Reaction:R-SSC-202472] Translocation of TRAF6 to CBM complex - Sus scrofa [Reaction:R-SSC-5607747] TRAF6 binds MALT1 oligomers - Sus scrofa [Reaction:R-SSC-446862] Hyperphosphorylated IRAK1 associates with TRAF6 - Sus scrofa [Reaction:R-SSC-507719] p62:MEKK3 binds to TRAF6 - Sus scrofa [Reaction:R-SSC-450173] IRAK1 induces oligomerisation of TRAF6 - Sus scrofa [Reaction:R-SSC-450173] IRAK1 induces oligomerisation of TRAF6 - Sus scrofa [Reaction:R-SSC-193695] IRAK interacts with TRAF6 - Sus scrofa [Reaction:R-SSC-193700] p75NTR ICD signals to NF-kB - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459233
displayName	TRAF6 [cytosol]
endCoordinate	522
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-SSC-918188] TRAF2, TRAF6 [cytosol] - Sus scrofa [DefinedSet:R-SSC-5690846] RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] - Sus scrofa
name	TRAF6 TRAF6 A7XUJ6
referenceEntity	[ReferenceGeneProduct:uniprot:A7XUJ6] UniProt:A7XUJ6
referenceType	ReferenceGeneProduct
repeatedUnitOf	[Polymer:R-SSC-2685708] TRAF6 oligomer [cytosol] - Sus scrofa
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-166366
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-SSC-8981951] IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] [Complex:R-SSC-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] [Complex:R-SSC-9645482] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] [Complex:R-SSC-1248657] TRAF6 E3/E2 ubiquitin ligase complex [cytosol] [Complex:R-SSC-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-SSC-937043] K63-linked polyUb p-IRAK1:TRAF6 [cytosol] [Complex:R-SSC-166867] MEKK1:activated TRAF6 [cytosol] [Complex:R-SSC-446864] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] [Complex:R-SSC-450121] p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] [Complex:R-SSC-450159] hp-IRAK1:3xTRAF6 [cytosol] [Complex:R-SSC-2685676] MALT1oligomer:TRAF6 [cytosol] [Complex:R-SSC-202471] TRAF6 trimer bound to CBM complex [plasma membrane] [Complex:R-SSC-5607701] p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] [Complex:R-SSC-507716] MAP3K3:SQSTM1:TRAF6 [cytosol] [Complex:R-SSC-197481] NF-kB:p75NTR ICD:TRAF6 [cytosol] [Complex:R-SSC-421373] TRAF6 homotrimer [cytosol] [Complex:R-SSC-209574] NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] [Complex:R-SSC-209569] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] [Complex:R-SSC-209565] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] [Complex:R-SSC-6783276] OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol]
(input)	[Reaction:R-SSC-936963] IRAK2 induces TRAF6 oligomerization [Reaction:R-SSC-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 [Reaction:R-SSC-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex [Reaction:R-SSC-936985] Activated TLR4:TICAM1 recruits TRAF6 [Reaction:R-SSC-166869] TRAF6 binds MEKK1 [Reaction:R-SSC-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments [Reaction:R-SSC-2730864] Recruitment of TRAF6 to CBM complex by binding to MALT1 [BlackBoxEvent:R-SSC-2730903] Oligomerization of TRAF6 [Reaction:R-SSC-202472] Translocation of TRAF6 to CBM complex [Reaction:R-SSC-5607747] TRAF6 binds MALT1 oligomers [Polymerisation:R-SSC-5607751] TRAF6 oligomerizes [Reaction:R-SSC-446862] Hyperphosphorylated IRAK1 associates with TRAF6 [Reaction:R-SSC-507719] p62:MEKK3 binds to TRAF6 [Reaction:R-SSC-450173] IRAK1 induces oligomerisation of TRAF6 [Reaction:R-SSC-193700] p75NTR ICD signals to NF-kB [Reaction:R-SSC-193695] IRAK interacts with TRAF6
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
(hasMember)	[DefinedSet:R-SSC-5690846] RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] [DefinedSet:R-SSC-918188] TRAF2, TRAF6 [cytosol] [DefinedSet:R-SSC-6782832] TRAF2,TRAF6,IKBKG,RIPK1 [cytosol]
(repeatedUnit)	[Polymer:R-SSC-2685708] TRAF6 oligomer [cytosol]
(activeUnit)	[CatalystActivity:10546203] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] [CatalystActivity:10479827] ubiquitin-protein transferase activity of hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] [CatalystActivity:10505464] ubiquitin-protein transferase activity of DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] [CatalystActivity:10467055] ubiquitin-protein transferase activity of TRAF6 trimer bound to CBM complex [plasma membrane] [CatalystActivity:10514662] ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] [CatalystActivity:10514667] ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane]

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