Reactome | lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

Schema > Reaction > Entries

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O Show undefined attributes

catalystActivity	[CatalystActivity:10448977] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of AASS tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448979
displayName	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
eventOf	[Pathway:R-SSC-71064] Lysine catabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Sus scrofa
inferredFrom	[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29444] L-Lys [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O 2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)
output	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] [SimpleEntity:R-ALL-30176] SACN [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70938
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
(inferredTo)	[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

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