Reactome | USP5 cleaves polyubiquitin

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10521501] cysteine-type deubiquitinase activity of USP5:PolyUb [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10521503
displayName	USP5 cleaves polyubiquitin
eventOf	[Pathway:R-SSC-5689880] Ub-specific processing proteases - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5690152] USP5 cleaves polyubiquitin - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-SSC-6782783] USP5:PolyUb [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	USP5 cleaves polyubiquitin
output	[DefinedSet:R-SSC-113595] Ub [cytosol] [Complex:R-SSC-6782795] USP5:Ub [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5690152
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-5689880] Ub-specific processing proteases
(inferredTo)	[Reaction:R-HSA-5690152] USP5 cleaves polyubiquitin

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